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Glycogen as source of glycogen phosphorylase inhibitor.
, Mejbaum-Katzenellenbogen +2 more
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Anomeric Spironucleosides of β-d-Glucopyranosyl Uracil as Potential Inhibitors of Glycogen Phosphorylase. [PDF]
Stathi A +3 more
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Role of Glycogen Phosphorylase in Liver Glycogen Metabolism
Molecular Aspects of Medicine, 2015Liver glycogen is synthesized after a meal in response to an increase in blood glucose concentration in the portal vein and endocrine and neuroendocrine signals, and is degraded to glucose between meals to maintain blood glucose homeostasis. Glycogen degradation and synthesis during the diurnal cycle are mediated by changes in the activities of ...
Loranne Agius
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Glycogen Phosphorylase Inhibitors
Mini-Reviews in Medicinal Chemistry, 2006Type 2 diabetes is a complex metabolic disease with hyperglycemia as its recognizable hallmark. Hepatic glucose output is elevated in Type 2 diabetic patients, and evidence suggests drugs which lower hepatic glucose production are effective antihyperglycemic agents.
Brad R, Henke, Steven M, Sparks
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Archives of Biochemistry and Biophysics, 1964
Abstract Brain glycogen phosphorylase has been shown to exist in an inactive and an active form. The inactive enzyme shows no activity in the absence of AMP but is maximally active in the presence of this nucleotide. The inactive enzyme has been purified 100-fold by adsorption on starch, followed by elution of other protein and finally elution of the
G I, DRUMMOND, J, KEITH, M W, GILGAN
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Abstract Brain glycogen phosphorylase has been shown to exist in an inactive and an active form. The inactive enzyme shows no activity in the absence of AMP but is maximally active in the presence of this nucleotide. The inactive enzyme has been purified 100-fold by adsorption on starch, followed by elution of other protein and finally elution of the
G I, DRUMMOND, J, KEITH, M W, GILGAN
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On the mechanism of glycogen phosphorylase
Archives of Biochemistry and Biophysics, 1972Abstract The rate of exchange of 18 O from the COP position into the external positions of the phosphate group of glucose 1-phosphate was studied. An indirect method, involving acid-catalyzed exchange of 18 O into the 1-position of glucose 6-phosphate followed by isomerization with phosphoglucomutase, was used to prepare a rapidly equilibrating ...
A M, Gold, M P, Osber
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Effect of polymyxins on glycogen phosphorylase
Biochemical and Biophysical Research Communications, 1980Abstract AMP-dependent activity of glycogen phosphorylase b is stimulated by the polymyxins A, B, D, and E. Kinetic studies indicate that these cyclic peptide antibiotics at low concentrations greatly enhance AMP-activation of the enzyme. The presence of polymyxins in the assay system leads to (a) partial desensitization of allosteric interactions ...
Ktenas, T. B. +4 more
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The interaction of muscle glycogen phosphorylase b with glycogen
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982Interaction of muscle glycogen phosphorylase b (EC 2.4.1.1) with glycogen was studied by sedimentation, stopped-flow and temperature-jump methods. The equilibrium enzyme concentration was determined by sedimentation in an analytical ultracentrifuge equipped with absorption optics and a photoelectric scanning system.
S V, Klinov +4 more
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