Results 191 to 200 of about 36,696 (264)

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, Volume 13, Issue 43, 3 August 2026.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Placenta Pathologies in Two Patients With Glycogen Storage Disease Type Ia and Preeclampsia. [PDF]

JIMD Rep
Laufs V, Hasenburg A, Busch MA, Lang F, Macchiella D, Mildenberger E, Seidmann L, Hennermann JB.   +7 more
europepmc   +1 more source

Prediction Model for Mild Cognitive Impairment in Older Chinese Patients With Cerebral Small Vessel Disease Based on XGBoost Algorithms and Shapley Additive Explanations

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
An interpretable XGBoost‐SHAP model predicted MoCA‐defined cognitive impairment in older patients with cerebral small vessel disease and identified reduced IGF‐1 as the leading predictor. The model showed strong validation performance and clinical utility, supporting early risk stratification.
Peng Gao, Jingjing Su, Xiaoming Ma, Xinwei Ma, Yujia Chen, Jiahui Shen, Yijie Wu, Cheng Shi, Jingwei Li   +8 more
wiley   +1 more source

Liver-Directed Gene Therapy Mitigates Early Nephropathy in Murine Glycogen Storage Disease Type Ia. [PDF]

J Inherit Metab Dis
Lee C, Pratap K, Zhang L, Chen HD, Arnaoutova I, Starost MF, Mansfield BC, Chou JY.   +7 more
europepmc   +1 more source

Estrogen Receptor Beta Activation Coordinates Liver Lipid Remodeling and Metabolic Fluxes, Preventing Lipotoxicity

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
ERβ activation restores glucose and lipid homeostasis by remodeling the hepatic lipidome. Mechanistically, it promotes complete fatty acid oxidation and decreases Acetyl‐CoA levels, leading to reduced ketogenesis and lipotoxicity, as demonstrated through in vivo and in vitro approaches.
Debora Santos Rocha, Eloisa Vilas‐Boas, Camille C. Caldeira da Silva, Everton L. Vogt, Marcos Yoshinaga, Mariana Pacheco Teixeira de Carvalho, Maiara I. C. Queiroz, Tiago Eugênio Oliveira da Silva, Sayuri Miyamoto, Alicia J. Kowaltowski   +9 more
wiley   +1 more source

Physical exercise intervention in glycogen storage disease IIIa: Feasibility and multisystem benefits. [PDF]

Exp Physiol
Bustos-Sellers A, Montalvo-Pérez A, Boraita A, Saco-Ledo G, Alejo LB, Barranco-Gil D, Valenzuela PL, López-Maldonado N, Ferrer-Costa R, Esparcia-Estrela J, Monteagudo-López C, Pinós T, Santos-Lozano A, Lucia A, Santalla A.   +14 more
europepmc   +1 more source

Galectin-3: a novel biomarker of glycogen storage disease type III. [PDF]

Cell Death Discov
Rossiaud L, Miagoux Q, Benabides M, Reiss O, Jauze L, Jarrige M, Polvèche H, Malfatti E, Laforêt P, Ronzitti G, Nissan X, Hoch L.   +11 more
europepmc   +1 more source

Growth impairment in glycogen storage disease type I versus types III/VI/IX: a cross-sectional study. [PDF]

BMC Pediatr
Wu X, Sun Y, Yang M.
europepmc   +1 more source

Interaction between neuromuscular junction metabolic requirements in fragile X syndrome and glycogen storage disease models. [PDF]

Dis Model Mech
Gurijala A, Rushton E, Leahy SN, Nelson N, Tessier CR, Broadie K.   +5 more
europepmc   +1 more source

Infant Born With Autosomal Recessive Glycogen Storage Disease Type IV due to Complete Maternal Isodisomy of Chromosome 3. [PDF]

Case Rep Genet
Olsen SS, Ernst A, Christensen PS, Björnsdóttir ED, Mark LR, Stefansen AV, Højland AT.   +6 more
europepmc   +1 more source