Results 1 to 10 of about 5,405 (144)

Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes. [PDF]

PLoS Neglected Tropical Diseases, 2016
It has long been thought that iminosugar antiviral activity is a function of inhibition of endoplasmic reticulum-resident α-glucosidases, and on this basis, many iminosugars have been investigated as therapeutic agents for treatment of infection by a ...
Andrew C Sayce, Dominic S Alonzi, Sarah S Killingbeck, Beatrice E Tyrrell, Michelle L Hill, Alessandro T Caputo, Ren Iwaki, Kyoko Kinami, Daisuke Ide, J L Kiappes, P Robert Beatty, Atsushi Kato, Eva Harris, Raymond A Dwek, Joanna L Miller, Nicole Zitzmann   +15 more
doaj   +2 more sources

Iminosugars of the Invasive Arboreal Amorpha fruticosa and Glycosidase Inhibition Potential [PDF]

Plants
Amorpha fruticosa L. (Fabaceae) originates from North America and has become an aggressive invasive plant in many parts of the world. It affects the local biodiversity in many negative ways. Our previous in vivo tests of purified extract of A.
Robert J. Nash, Barbara Bartholomew, Yana B. Penkova, Ekaterina Kozuharova   +3 more
doaj   +2 more sources

Antiviral therapies targeting host ER alpha-glucosidases: Current status and future directions [PDF]

Antiviral Research, 2013
Ju-Tao Guo, Timothy Block, Jinhong Chang   +2 more
exaly   +2 more sources

Peptide modulators of alpha‐glucosidase [PDF]

Journal of Diabetes Investigation, 2015
AbstractAims/IntroductionAcute glucose fluctuations during the postprandial period pose great risk for cardiovascular complications and thus represent an important therapeutic approach in type 2 diabetes. In the present study, screening of peptide libraries was used to select peptides with an affinity towards mammalian intestinal alpha‐glucosidase as ...
Irena Roskar, Peter Molek, Miha Vodnik, Mateja Stempelj, Borut Strukelj, Mojca Lunder   +5 more
openaire   +2 more sources

Alpha-glucosidase promotes hemozoin formation in a blood-sucking bug: an evolutionary history. [PDF]

PLoS ONE, 2009
BackgroundHematophagous insects digest large amounts of host hemoglobin and release heme inside their guts. In Rhodnius prolixus, hemoglobin-derived heme is detoxified by biomineralization, forming hemozoin (Hz).
Flávia Borges Mury, José Roberto da Silva, Ligia Souza Ferreira, Beatriz dos Santos Ferreira, Gonçalo Apolinário de Souza-Filho, Jayme Augusto de Souza-Neto, Paulo Eduardo Martins Ribolla, Carlos Peres Silva, Viviane Veiga do Nascimento, Olga Lima Tavares Machado, Marília Amorim Berbert-Molina, Marilvia Dansa-Petretski   +11 more
doaj   +1 more source

Salivary Digestion Extends the Range of Sugar-Aversions in the German Cockroach

Insects, 2021
Saliva has diverse functions in feeding behavior of animals. However, the impact of salivary digestion of food on insect gustatory information processing is poorly documented.
Ayako Wada-Katsumata, Coby Schal
doaj   +1 more source

alfa e b-glucosidases como alvos moleculares para desenvolvimento de fármacos alpha and beta-glucosidases as molecular targets for drug development

Química Nova, 2006
Glucosidases are involved in key steps in the processing of oligosaccharides by cleaving O-glucose residues. Since they catalyze breaking and transfer reactions of glucosidic groups for the normal growth and development of all the cells, defects or ...
Eduardo Borges de Melo, Ivone Carvalho
doaj   +1 more source

Cloning and Molecular Characterization of an Alpha-Glucosidase (MalH) from the Halophilic Archaeon Haloquadratum walsbyi

Life, 2017
We report the heterologous expression and molecular characterization of the first extremely halophilic alpha-glucosidase (EC 3.2.1.20) from the archaeon Haloquadratum walsbyi. A 2349 bp region (Hqrw_2071) from the Hqr.
Mara F. Cuebas-Irizarry, Ricardo A. Irizarry-Caro, Carol López-Morales, Keyla M. Badillo-Rivera, Carlos M. Rodríguez-Minguela, Rafael Montalvo-Rodríguez   +5 more
doaj   +1 more source

Clinical, muscle pathology and molecular biological features of late ⁃ onset glycogen storage disease typeⅡ

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To summarize the clinical, muscle pathology and molecular biological features of late⁃onset glycogen storage disease type Ⅱ (GSDⅡ). Methods and Results Five patients with late⁃onset GSD Ⅱ diagnosed and treated in The Fifth Affiliated Hospital ...
WU Shi⁃tao, LIU Fang , SHI Wei⁃wei , ZHANG Min, LIU Heng⁃fang   +4 more
doaj   +1 more source

The Santorini Volcanic Complex as a Valuable Source of Enzymes for Bioenergy

Energies, 2021
Marine microbial communities are an untapped reservoir of genetic and metabolic diversity and a valuable source for the discovery of new natural products of biotechnological interest.
Paraskevi N. Polymenakou, Paraskevi Nomikou, Haris Zafeiropoulos, Manolis Mandalakis, Thekla I. Anastasiou, Stephanos Kilias, Nikos C. Kyrpides, Georgios Kotoulas, Antoniοs Magoulas   +8 more
doaj   +1 more source