Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes. [PDF]
PLoS Neglected Tropical Diseases, 2016 It has long been thought that iminosugar antiviral activity is a function of inhibition of endoplasmic reticulum-resident α-glucosidases, and on this basis, many iminosugars have been investigated as therapeutic agents for treatment of infection by a ...
Andrew C Sayce +15 more
doaj +2 more sources
Iminosugars of the Invasive Arboreal Amorpha fruticosa and Glycosidase Inhibition Potential [PDF]
PlantsAmorpha fruticosa L. (Fabaceae) originates from North America and has become an aggressive invasive plant in many parts of the world. It affects the local biodiversity in many negative ways. Our previous in vivo tests of purified extract of A.
Robert J. Nash +3 more
doaj +2 more sources
Alpha-1 antitrypsin deficiency gut microbiome [PDF]
, 2020 This dataset contains 16S rRNA Illumina MiSeq sequenced samples used in our gut microbiome study in individuals with alpha-1 antitrypsin deficiency (AATD) and controls (non-AATD)
Kirst, ME (University of Florida)
core +1 more source
Synthesis and Evaluation of Aminocyclopentitol Inhibitors of β-Glucosidases [PDF]
, 2016 (1R,2S,3S,4R,5R)-4-Amino-5-(hydroxymethyl)cyclopentane-1,2,3-triol 1, prepared from d-glucose, inhibits β-glucosidases from Caldocellum saccharolyticum (Ki = 1.8 × 10-7 M) and from almonds (Ki = 3.4 × 10-6 M). Inhibition is not influenced by N-ethylation
Emmanuel Leroy (3076077) +3 more
core +1 more source
Structual and biochemical characterisation of the endoplasmic reticulum alpha-glucosidases [PDF]
, 2015 ER alpha-glucosidases I and II are glycosyl hydrolases that play a key role in eukaryotic glycoprotein folding quality control. Removal of two glucose residues from the N-glycan attached to a protein allows association with calnexin or calreticulin which
Caputo, Alessandro T. +1 more
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The Alpha Centauri Scientific and Technological Research Journal is a peer-reviewed journal produced internationally, it is published QUARTERLY in online version ISSN: 2709-4502. Alpha Centauri publishes scientific articles specializing in Applied Social
Diaz Dumont, Jorge Rafael
core +20 more sources
MOESM1 of Using the β-glucosidase catalyzed reaction product glucose to improve the ionic liquid tolerance of β-glucosidases [PDF]
, 2016 Additional file 1: Figure S1 . Sequence alignment of H0HC94 against the previously known Agrobacterium β-glucosidases. Full-length amino acid sequences were aligned by ClustalW2 (1) followed by alignment in the Espript 3.X programme (2).
Neha Gupta (160000) +2 more
core +1 more source
Voglibose: An Alpha Glucosidase Inhibitor
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013 Diabetes Mellitus (DM) is a morbid disease worldwide, with increasing incidence as time passes. It has macro-vascular and micro-vascular complications. The main cause of these complications is poorly controlled postprandial hyperglycaemia. Alpha glucosidase inhibitors, namely acarbose, voglibose and miglitol, are available for therapy.
Ajay S. Dabhi +2 more
openaire +3 more sources
Structure and Function Insight of the α-Glucosidase QsGH13 From Qipengyuania seohaensis sp. SW-135
Frontiers in Microbiology, 2022 The α-glucosidases play indispensable roles in the metabolic mechanism of organism, prevention, and treatment of the disease, and sugar hydrolysis, and are widely used in chemical synthesis, clinical diagnosis, and other fields.
Xingyu Zhai +8 more
doaj +1 more source
Sugar digestion in mosquitoes: Identification and characterization of three midgut alpha-glucosidases of the neo-tropical malaria vector Anopheles aquasalis (Diptera : Culicidae) [PDF]
, 2007 Dietary carbohydrates provide an important source of energy for flight, and contribute to longevity and fecundity of mosquitoes. The most common sugar mosquitoes ingest is sucrose, and digestion of this substance is carried out mainly by alpha ...
Souza-Neto, Jayme A. +4 more
core +1 more source