BioEssays, EarlyView.Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley +1 more source
Fluorescent nanodiamonds for FRET-based monitoring of a single biological nanomotor FoF1-ATP synthase [PDF]
, 2009 Color centers in diamond nanocrystals are a new class of fluorescence markers that attract significant interest due to matchless brightness, photostability and biochemical inertness. Fluorescing diamond nanocrystals containing defects can be used as markers replacing conventional organic dye molecules, quantum dots or autofluorescent proteins. They can
arxiv +1 more source
Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation [PDF]
, 2015 Increasing evidence suggests that recurrent Herpes Simplex Virus type 1 (HSV-1) infection spreading to the CNS is a risk factor for Alzheimer's Disease (AD) but the underlying mechanisms have not been fully elucidated yet.
De Chiara, Giovanna +7 more
core +2 more sources
The Role of Glycogen Synthase Kinase 3 Beta in Neuroinflammation and Pain.
Journal of Pharmacy and Pharmacology, 2013 Neuroinflammation is a crucial mechanism related to many neurological diseases. Extensive studies in recent years have indicated that dysregulation of Glycogen Synthase Kinase 3 Beta (GSK3β) contributes to the development and progression of these ...
D. Maixner, H. Weng
semanticscholar +1 more source
Frontiers in Physiology, 2019 Harmonia axyridis is an important predatory insect and widely used in biological control of agricultural and forestry pests. Trehalose is directly involved in the energy storage of the H.
Yan Li +6 more
doaj +1 more source
The Energy Sensor AMPK: Adaptations to Exercise, Nutritional and Hormonal Signals [PDF]
Spiegelman B. Hormones, Metabolism and the Benefits of Exercise,
Hormones, Metabolism and the Benefits of Exercise, Springer, pp.13-24, 2018,
Research and Perspectives in Endocrine Interactions, 978-3-319-72789-9, 2019 To sustain metabolism, intracellular ATP concentration must be regulated within an appropriate range. This coordination is achieved through the function of the AMP-activated protein kinase (AMPK), a cellular "fuel gauge" that is expressed in essentially all eukaryotic cells as heterotrimeric complexes containing catalytic $\alpha$ subunits and ...
arxiv
Monitoring transient elastic energy storage within the rotary motors of single FoF1-ATP synthase by DCO-ALEX FRET [PDF]
, 2012 The enzyme FoF1-ATP synthase provides the 'chemical energy currency' adenosine triphosphate (ATP) for living cells. Catalysis is driven by mechanochemical coupling of subunit rotation within the enzyme with conformational changes in the three ATP binding sites.
arxiv +1 more source
Exploration of the Neuronal Subtype Specificity of an Ethanol Responsive Gene: Glycogen Synthase Kinase 3 Beta (Gsk3b) [PDF]
, 2020 Exploration of the Neuronal Subtype Specificity of an Ethanol Responsive Gene: Glycogen Synthase Kinase 3 Beta (Gsk3b) Dalton Huey, Depts. of Bioinformatics, Biology & Chemistry, A. van der Vaart, G. M. Harris, and M. F. Miles, with Dr.
Harris, G M +3 more
core +1 more source
Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity [PDF]
, 2011 Insulin resistance has been associated with the progression of chronic kidney disease in both diabetes and obesity. In order to determine the cellular mechanisms contributing to this, we characterized insulin signaling in renal tubules and glomeruli ...
Cahill, Christopher +10 more
core +1 more source
DAF-16/FoxO in Caenorhabditis elegans and its role in metabolic remodeling [PDF]
, 2020 DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional changes in many genes involved in aging, development, stress, metabolism, and ...
Braeckman, Bart, Zečić, Aleksandra
core +1 more source