Results 121 to 130 of about 448,615 (401)
Activity-Dependent Regulation of Dendritic Growth and Maintenance by Glycogen Synthase Kinase 3β
Nature Communications, 2013 Activity-dependent dendritic development represents a crucial step in brain development, but its underlying mechanisms remain to be fully elucidated. Here we report that glycogen synthase kinase 3β (GSK3β) regulates dendritic development in an activity ...
Yanfang Rui +6 more
semanticscholar +1 more source
Glycogen Synthase Kinase–3 and the Heart∗
Journal of the American College of Cardiology, 2014 Over the past decade, optimism has been high for the potential clinical significance of glycogen synthase kinase–3 (GSK-3) as a pharmacological target for ischemia and heart failure, as well as diabetes, Parkinson’s disease, and Alzheimer’s disease.
openaire +3 more sources
Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities
Cancer Communications, EarlyView.Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan +13 more
wiley +1 more source
Inositols in Insulin Signaling and Glucose Metabolism [PDF]
, 2018 In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of
Bevilacqua, Arturo, Bizzarri, Mariano
core +1 more source
Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation [PDF]
The EMBO Journal, 2004 Glycogen and starch are the major readily accessible energy storage compounds in nearly all living organisms. Glycogen is a very large branched glucose homopolymer containing about 90% alpha-1,4-glucosidic linkages and 10% alpha-1,6 linkages. Its synthesis and degradation constitute central pathways in the metabolism of living cells regulating a global
Buschiazzo, Alejandro +5 more
openaire +6 more sources
Promising Prodiginins Biological Activities
Chemistry &Biodiversity, EarlyView.ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto +6 more
wiley +1 more source
Observing single FoF1-ATP synthase at work using an improved fluorescent protein mNeonGreen as FRET donor [PDF]
, 2016 Adenosine triphosphate (ATP) is the universal chemical energy currency for cellular activities provided mainly by the membrane enzyme FoF1-ATP synthase in bacteria, chloroplasts and mitochondria. Synthesis of ATP is accompanied by subunit rotation within the enzyme.
arxiv +1 more source
Production of amylopectin and high-amylose starch in separate potato genotypes [PDF]
, 2004 Starch is one of the most important processed products from agriculture. Two main outlets can be identified; starch is either enzymatically processed for the production of sweeteners and as raw material for fermentation or channelled to various ...
Hofvander, Per
core
Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition
Chemistry &Biodiversity, Accepted Article.Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb +5 more
wiley +1 more source
Glycogen synthase kinases 3α and 3β in cardiac myocytes: regulation and consequences of their inhibition [PDF]
, 2008 Inhibition of glycogen synthase kinase 3β (GSK3β) as a consequence of its phosphorylation by protein kinase B/Akt (PKB/Akt) has been implicated in cardiac myocyte hypertrophy in response to endothelin-1 or phenylephrine.
Alsafi, Ali +7 more
core +1 more source