Results 121 to 130 of about 149,215 (350)

GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals

Neurobiology of Disease, 2009
The dysregulation of glycogen synthase kinase-3 (GSK3) has been implicated in Alzheimer disease (AD) pathogenesis and in Aβ-induced neurotoxicity, leading us to investigate it as a therapeutic target in an intracerebroventricular Aβ infusion model ...
Shuxin Hu, Aynun N. Begum, Mychica R. Jones, Mike S. Oh, Walter K. Beech, Beverly Hudspeth Beech, Fusheng Yang, Pingping Chen, Oliver J. Ubeda, Peter C. Kim, Peter Davies, Qiulan Ma, Greg M. Cole, Sally A. Frautschy   +13 more
doaj   +1 more source

Structure–activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors

, 2023
Guanglin Luo, Ling Chen, Swanee Jacutin-Porte, Ying Han, Catherine R. Burton, Hong Xiao, Carol Krause, Yang Cao, Nengyin Liu, Kevin Kish, H.A. Lewis, John E. Macor, Gene M. Dubowchik   +12 more
openalex   +1 more source

Buck Wheat: Nutritional, Bioactive Characteristics, Health Benefits, and Side Effects

Future Postharvest and Food, EarlyView.
ABSTRACT Micronutrient deficits have resulted from an over‐reliance on a small number of cereal crops for food security. The agricultural sector faces severe sustainability issues due to the rapid growth of the world's population and sudden climatic changes.
Momina Farooq, Sajad Ahmad Mir, Zahida Naseem   +2 more
wiley   +1 more source

Glycogen is a neutral cargo of bulk autophagy in Komagataella phaffii

Autophagy Reports
Glycogen is a primary cellular energy store in numerous eukaryotes. Its biosynthesis is a main strategy to cope with forthcoming starvation. During starvation, glycogen is processed in the cytosol or delivered for degradation to animal lysosomes or yeast
Nimna V. Wijewantha, Taras Y. Nazarko
doaj   +1 more source

Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors

Molecules, 2018
Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine protein kinase that was originally identified as an enzyme involved in the control of glycogen metabolism.
Daniela Hulcová, Kateřina Breiterová, Tomáš Siatka, Kamila Klímová, Lara Davani, Marcela Šafratová, Anna Hošťálková, Angela De Simone, Vincenza Andrisano, Lucie Cahlíková   +9 more
doaj   +1 more source

Possible mechanism for changes in glycogen metabolism in unloaded soleus muscle [PDF]

Carbohydrate metabolism has been shown to be affected in a number of ways by different models of hypokinesia. In vivo glycogen levels in the soleus muscle are known to be increased by short-term denervation and harness suspension.
Henriksen, E. J., Tischler, M. E.
core   +1 more source

Local anaesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro

, 2016
Retrospective studies indicate that the use of regional anesthesia can reduce cancer recurrence after surgery which could be due to ranging from immune function preservation to direct molecular mechanisms.
Chen, L, Hankin, J, Ma, D, Xuan, W, Yao, S, Zhao, H   +5 more
core   +3 more sources

Ketamine: synaptogenesis, immunomodulation and glycogen synthase kinase-3 as underlying mechanisms of its antidepressant properties [PDF]

, 2013
Patricia A. Zunszain, Mark Horowitz, Annamaria Cattaneo, Micol Lupi, Carmine M. Pariante   +4 more
openalex   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

A novel glycogen synthase kinase‐3 inhibitor 2‐methyl‐5‐(3‐{4‐[(S )‐methylsulfinyl]phenyl}‐1‐benzofuran‐5‐yl)‐1,3,4‐oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease [PDF]

, 2011
Tomohiro Onishi, Hiroki Iwashita, Yumiko Uno, Jun Kunitomo, Morihisa Saitoh, Eiji Kimura, Hisashi Fujita, Noriko Uchiyama, Masakuni Kori, Masayuki Takizawa   +9 more
openalex   +1 more source