Results 261 to 270 of about 454,859 (358)

From fibro/adipogenic progenitors to adipocytes: Understanding adipogenesis in muscle degeneration for disease modulation

The Journal of Physiology, EarlyView.
Abstract figure legend Fibro/adipogenic progenitors (FAPs) are cells resident in the muscle (skeletal and cardiac) niche. FAPs are active participants in the process of muscle degeneration in cardiovascular and neuromuscular diseases. Here, the accumulation of fatty and fibrous tissue is a hallmark.
Elisa Villalobos, Priyanka Mehra, Jordi Diaz‐Manera   +2 more
wiley   +1 more source

Sex differences in insulin regulation of skeletal muscle glycogen synthase and changes during weight loss and exercise in adults. [PDF]

Obesity (Silver Spring)
Ryan AS, Li G, McMillin S, Ortmeyer HK.
europepmc   +1 more source

Mechanisms of haemoglobin mass expansion following heat stress

The Journal of Physiology, EarlyView.
Abstract figure legend Theorised mechanisms of heat stress‐induced erythropoiesis which may facilitate the expansion of haemoglobin mass. A, acute: heat stress‐induced renal ischaemia. Redistribution of blood flow away from the kidneys to facilitate thermoregulation during heat stress could reduce renal oxygen delivery, subsequently lowering renal PO2${
Elliott J. Jenkins, Brittany A. Edgett, Michael G. Hughes, Joshua C. Tremblay, Mike Stembridge   +4 more
wiley   +1 more source

Glycogen synthase kinase-3 is essential for T_regdevelopment and function

Kandasamy M, Andrew HF, Raza IG, Mitchell R, Borsa M, Attar M, Clarke AJ.   +6 more
europepmc   +1 more source

Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders. [PDF]

Sci Transl Med
Ullman JC, Mellem KT, Xi Y, Ramanan V, Merritt H, Choy R, Gujral T, Young LEA, Blake K, Tep S, Homburger JR, O'Regan A, Ganesh S, Wong P, Satterfield TF, Lin B, Situ E, Yu C, Espanol B, Sarwaikar R, Fastman N, Tzitzilonis C, Lee P, Reiton D, Morton V, Santiago P, Won W, Powers H, Cummings BB, Hoek M, Graham RR, Chandriani SJ, Bainer R, DePaoli-Roach AA, Roach PJ, Hurley TD, Sun RC, Gentry MS, Sinz C, Dick RA, Noonberg SB, Beattie DT, Morgans DJ, Green EM.   +43 more
europepmc   +1 more source

Axil, a Member of the Axin Family, Interacts with Both Glycogen Synthase Kinase 3β and β-Catenin and Inhibits Axis Formation ofXenopus Embryos

, 1998
Hideki Yamamoto, Shosei Kishida, Takaaki Uochi, Satoshi Ikeda, Shinya Koyama, Makoto Asashima, Akira Kikuchi   +6 more
openalex   +2 more sources

Multi‐omic data integration and exploiting metabolic models using systems biology approach increase precision in subtyping and early diagnosis of cancer

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Ezgi Tanıl, Emrah Nikerel
wiley   +1 more source

The Effects of Food on Circadian Rhythm: A Comprehensive Review

eFood, Volume 6, Issue 5, October 2025.
(a) Light signals are received by the retina and transmitted to the suprachiasmatic nucleus (SCN), the master circadian clock, which synchronizes peripheral clocks in metabolic tissues via neural and humoral pathways (e.g., cortisol). (b) The molecular clock is governed by a transcriptional‐translational feedback loop.
Jiazheng Hu, Hongyu Ye, Mengxin Wang, Han Yang, Manxi Wu, Jinping Cao, Chongde Sun, Yue Wang   +7 more
wiley   +1 more source

Targeted inhibition of glycogen synthase kinase-3 using 9-ING-41 (elraglusib) enhances CD8 T-cell-reactivity against neuroblastoma cells. [PDF]

Sci Rep
Markovska A, Somers K, Guillaume J, Melief J, Mazar AP, Schmitt DM, Schipper HS, Boes M.   +7 more
europepmc   +1 more source

Does Lithium Lower the Risk of Glaucoma—A Danish Nationwide Study

Acta Psychiatrica Scandinavica, Volume 152, Issue 4, Page 308-315, October 2025.
ABSTRACT Background Glaucoma is an optic neuropathy caused by neurodegenerative loss of retinal ganglion cells (RGC). Mechanisms that contribute to RGC death include some of the same mechanisms involved in bipolar disorders (BD) and are the same mechanisms which are targeted by lithium (Li).
Tomas Hajek, Orestes Forlenza, Marcelo Nicolela, Ann‐Eva Christensen, Henrik Vorum, René Ernst Nielsen   +5 more
wiley   +1 more source