Results 261 to 270 of about 149,215 (350)

Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes

Glia, Volume 74, Issue 2, February 2026.
CD38 deficiency influences brain NAD/NAM metabolism. Global CD38 deficiency drives changes in astrocyte mitochondrial, metabolic, senescence, and neurodegenerative‐related genes. CD38 deficiency alters glial reactivity and astrocyte bioenergetics. ABSTRACT CD38 is an ectoenzyme that converts NAD+ to NAM to help maintain bioenergetic homeostasis.
S. Basak, A. M. Colafrancesco, R. D. Hernandez, X. Wei, L. J. McMeekin, D. Dang, M. Simmons, J. L. Browning, K. Noel, F. Zhou, F. E. Lund, J. S. Saad, S. G. Watsen, A. M. Pickrell, R. M. Cowell, M. L. Olsen   +15 more
wiley   +1 more source

Identification of a novel pyrrolo[2,3-<i>b</i>]pyridine compound as a potent glycogen synthase kinase 3β inhibitor for treating Alzheimer's disease. [PDF]

J Enzyme Inhib Med Chem
Xun QQ, Zhang J, Feng L, Ma YY, Li Y, Shi XL.   +5 more
europepmc   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Glycogen synthase kinase 3 inhibition controls Mycobacterium tuberculosis infection. [PDF]

iScience
Peña-Díaz S, Chao JD, Rens C, Haghdadi H, Zheng X, Flanagan K, Ko M, Shapira T, Richter A, Maestre-Batlle D, Canseco JO, Gutierrez MG, Duc KD, Pelech S, Av-Gay Y.   +14 more
europepmc   +1 more source

Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Aging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Madison Milan, Eva Troyano‐Rodriguez, Jennifer Ihuoma, Sharon Negri, Rakesh Rudraboina, Aleksandra Kosmider, Shantipriya Awasthi, Priya Balasubramanian, Shannon Conley, Andriy Yabluchanskiy, Anna Csiszar, Zoltan Ungvari, Rafael de Cabo, Stefano Tarantini   +13 more
wiley   +1 more source

Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction. [PDF]

Open Med (Wars)
Wang M, Qu Y, Wang S, Qu Z.
europepmc   +1 more source

Regulation of thymocyte β-selection, development and positive selection by glycogen synthase kinase-3

, 2019
Maddy Parsons, Satish Patel, Bradley W. Doble, Pamela S. Ohashi, James R. Woodgett   +4 more
openalex   +1 more source

Selection for Postponed Senescence in Drosophila melanogaster Reveals Distinct Metabolic Aging Trajectories Modifiable by the Angiotensin‐Converting Enzyme Inhibitor Lisinopril

Aging Cell, Volume 25, Issue 2, February 2026.
Assessment of oxygen consumption rates in young, middle‐aged, and old flies from the Drosophila B lines and long‐lived O lines revealed a significant increase in metabolic rate with aging only in B flies. Lisinopril prevented the age‐related rise in metabolic rate in B female flies.
Denise Vecchié, Robert R. H. Anholt, Trudy F. C. Mackay, Maria De Luca   +3 more
wiley   +1 more source

Natural compounds from herbs and nutraceuticals as glycogen synthase kinase-3β inhibitors in Alzheimer's disease treatment. [PDF]

CNS Neurosci Ther
Zhao Z, Yuan Y, Li S, Wang X, Yang X.
europepmc   +1 more source

The tandem–random transition of cellular patterning: proposed roles of N‐cadherin‐based orientational cell adhesions in the development, maintenance, and degeneration of the nucleus pulposus

Biological Reviews, Volume 101, Issue 1, Page 268-278, February 2026.
ABSTRACT Intervertebral disc degeneration (IDD) can contribute to lower back and neck pain. In IDD, the most affected component of the intervertebral disc is the nucleus pulposus (NP). Derived from the notochord, where cells are organized into a tandem configuration, young NP cells cluster in three‐dimensional (3D) networks embedded in a gelatinous ...
Xiangyun Wei, Nam Vo, Gwendolyn A. Sowa
wiley   +1 more source