Genetic reduction of skeletal muscle glycogen synthase 1 abundance reveals that the refeeding-induced reversal of elevated insulin-stimulated glucose uptake after exercise is not attributable to achieving a high muscle glycogen concentration. [PDF]
FASEB JKwak SE +4 more
europepmc +1 more source
British Journal of Pharmacology, Volume 182, Issue 19, Page 4625-4646, October 2025.Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran +9 more
wiley +1 more source
British Journal of Pharmacology, Volume 182, Issue 19, Page 4668-4692, October 2025.Background and Purpose Hidden cardiotoxicity is defined as drug‐induced cardiotoxicity that becomes obvious only in the presence of comorbidities. However, the molecular mechanisms of hidden cardiotoxicity are not always known. Therefore, unbiased multi‐omics approaches could assist in revealing regulatory pathways.
Bennet Y. Weber +12 more
wiley +1 more source
Glucose Metabolic Reprogramming in Colorectal Cancer: From Mechanisms to Targeted Therapy Approaches
Cancer Medicine, Volume 14, Issue 17, September 2025.ABSTRACT Background Colorectal cancer (CRC) is one of the most common malignant tumors, and its morbidity ranks third among all cancers, with a trend toward younger patients. Metabolic reprogramming, a unique metabolic mode in tumor cells, is closely related to the occurrence and development of CRC. Numerous studies have confirmed that many genetic and
Runkai Zhou +4 more
wiley +1 more source
Dexmedetomidine regulates exosomal miR-29b-3p from macrophages and alleviates septic myocardial injury by promoting autophagy in cardiomyocytes via targeting glycogen synthase kinase 3β. [PDF]
Burns TraumaYu T +9 more
europepmc +1 more source
Food Science &Nutrition, Volume 13, Issue 9, September 2025.Polyphenols, known for their antioxidant and anti‐inflammatory properties, show strong potential in mitigating Alzheimer's disease by targeting oxidative stress, neuroinflammation, amyloid‐beta aggregation, and tau hyperphosphorylation. Preclinical and in silico studies highlight compounds like resveratrol, curcumin, and epigallocatechin gallate for ...
Guifei Chen +4 more
wiley +1 more source
Glycogen synthase kinase 3β: the nexus of chemoresistance, invasive capacity, and cancer stemness in pancreatic cancer. [PDF]
Cancer Drug ResistUehara M +6 more
europepmc +1 more source
Delivering the Message: Translating mRNA Therapy for Liver Inherited Metabolic Diseases
Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.ABSTRACT mRNA encapsulated in lipid nanoparticles (LNPs) provides a dual revolution in the field of gene therapy. mRNA brings fleeting efficacy and the possibility to adjust the therapy to clinical needs. LNP, as a non‐viral vehicle with flexible organ‐targeting, overcomes most immune complications of viral gene therapy. mRNA‐LNP has rapidly progressed
Sonam Gurung +4 more
wiley +1 more source
Heavy Metals Toxicity: Mechanism, Health Effects, and Therapeutic Interventions
MedComm, Volume 6, Issue 9, September 2025.Heavy metals exert a wide range of effects at the cellular, molecular, and genetic levels, leading to neurological damage, renal dysfunction, cardiovascular disease, reproductive developmental abnormality, immune system abnormality, and increased risk of cancer by interfering with biomolecule function, signaling pathways, inducing oxidative stress, and
Yu‐feng Cheng +3 more
wiley +1 more source