This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li +8 more
wiley +1 more source
Identification of biomarkers associated with glycolysis and lactation in sarcopenia. [PDF]
Luo X +11 more
europepmc +1 more source
A note on the action of tannin upon tumour glycolysis [PDF]
A. Lasnitzki
openalex +1 more source
Glycolysis in retinal extracts [PDF]
Margherita Cotonio Bourne +1 more
openaire +3 more sources
Glycoprotein Ib activation by thrombin stimulates the energy metabolism in human platelets [PDF]
Corona de la Pena, Norma +4 more
core +3 more sources
Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond
Dental stem cell (DSC) aging involves genomic instability, mitochondrial dysfunction, telomere attrition, and epigenetic alterations, leading to impaired proliferation, reduced differentiation potential, and pro‐inflammatory secretory activity. These processes drive cellular senescence and compromise regenerative and immunomodulatory functions, thereby
Xinyuan Zhao +7 more
wiley +1 more source
Glycolytic reprogramming during microglial polarization in neurological diseases. [PDF]
Li X, Fang C, Li Y, Xiong X, Xu X, Gu L.
europepmc +1 more source
Targeting Methylglyoxal Metabolism to Enhance Ferroptosis Sensitivity in Tumor Therapy
This study reveals how blocking a detox enzyme called GLO1 increases the buildup of a toxic molecule, methylglyoxal (MGO), which triggers cancer cell death by ferroptosis. A protein called PJA1 drives this process. Targeting the PJA1–GLO1 pathway boosts the effectiveness of ferroptosis‐inducing treatments in tumors, offering a promising approach for ...
Xinyue Zhang +9 more
wiley +1 more source
Integrated multi-omics analysis reveals a glycolytic signature that predicts pan-cancer immune checkpoint inhibitor response and LDHA as a combinatorial target in fumarate hydratase-deficient renal cell carcinoma. [PDF]
Liu S +7 more
europepmc +1 more source

