Results 211 to 220 of about 422,950 (380)

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

open access: yesAdvanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li   +8 more
wiley   +1 more source

Identification of biomarkers associated with glycolysis and lactation in sarcopenia. [PDF]

open access: yesSci Rep
Luo X   +11 more
europepmc   +1 more source

Glycolysis in retinal extracts [PDF]

open access: yesBiochemical Journal, 1940
Margherita Cotonio Bourne   +1 more
openaire   +3 more sources

Glycoprotein Ib activation by thrombin stimulates the energy metabolism in human platelets [PDF]

open access: yes, 2017
Corona de la Pena, Norma   +4 more
core   +3 more sources

Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond

open access: yesAdvanced Science, EarlyView.
Dental stem cell (DSC) aging involves genomic instability, mitochondrial dysfunction, telomere attrition, and epigenetic alterations, leading to impaired proliferation, reduced differentiation potential, and pro‐inflammatory secretory activity. These processes drive cellular senescence and compromise regenerative and immunomodulatory functions, thereby
Xinyuan Zhao   +7 more
wiley   +1 more source

Targeting Methylglyoxal Metabolism to Enhance Ferroptosis Sensitivity in Tumor Therapy

open access: yesAdvanced Science, EarlyView.
This study reveals how blocking a detox enzyme called GLO1 increases the buildup of a toxic molecule, methylglyoxal (MGO), which triggers cancer cell death by ferroptosis. A protein called PJA1 drives this process. Targeting the PJA1–GLO1 pathway boosts the effectiveness of ferroptosis‐inducing treatments in tumors, offering a promising approach for ...
Xinyue Zhang   +9 more
wiley   +1 more source

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