Results 201 to 210 of about 454,150 (248)

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

Proteomic profiling identifies serpin G1, ApoA-II, and LBP as potential biomarkers of dementia in an Egyptian cohort. [PDF]

Alzheimers Dement (Amst)
Heikal SA, Khedr EM, Othman M, Elsheikh NG, Tawfik HM, Hassanin HI, Al-Shehaby N, Eltaher A, Shamma S, Mohamed AS, Saber M, Lomomba AA, Ali E, Safwat SM, Elfetoh NA, Fawi G, Yousri NA, Salama M.   +17 more
europepmc   +1 more source

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

Association between alpha-1-acid glycoprotein and frailty in US females aged 20-49 years: analysis of NHANES data (2015-2023). [PDF]

Sci Rep
Liu Y, Chen Y, Zhou L, Yin Y, Cao Y, Li G, Xu T, Wen X.   +7 more
europepmc   +1 more source

Mucociliary Clearance Inspired Nanozyme‐centric Hydrogel Composites for Integrated Bacterial Detection

Advanced Science, EarlyView.
Inspired by human pulmonary cilia and their mucus defend against bacteria, nanozyme‐centric hydrogel networks have been assembled into nanowires, combining the rapid penetration capability of the nanowire arrays with the adhesion and detection functions of the nanozyme‐centric hydrogel networks.
Zhaoling Tan, Xuejiao Wang, Zhaoyue Wang, Jieke Jiang, Xi Yao   +4 more
wiley   +1 more source

Lyssavirus Antibody Detection in Cave-Dwelling Bats on Cat Ba Island, Vietnam: Implications for Zoonotic Surveillance. [PDF]

Vet Sci
Dundarova H, Chassovnikarova T, Todorova N, Beltcheva M, Aleksieva I, Luong NT, Thong VD.   +6 more
europepmc   +1 more source

Management and burden of disease in people with myelin oligodendrocyte glycoprotein antibody-associated disease: data from an international, cross-sectional survey. [PDF]

J Neurol
Paul F, Zappacosta S, Narduzzi S, Khellaf M, Unsworth M, Trenholm E, Levy M.   +6 more
europepmc   +1 more source

Potent Inhibition of Chikungunya Virus Entry by a Pyrazole-Benzene Derivative: A Computational Study Targeting the E1-E2 Glycoprotein Complex. [PDF]

Int J Mol Sci
Rahman MM, Limon MBH, Saikat TA, Saha P, Nahid AH, Alam MM, Rahman MZ.   +6 more
europepmc   +1 more source

Targeting conserved epitopes in structural proteins: a next-generation vaccine strategy against the newly identified HKU5-CoV-2 virus. [PDF]

Signal Transduct Target Ther
de Araújo LP, Silva EN, Costa ALC, Corsetti PP, de Almeida LA.   +4 more
europepmc   +1 more source