Results 221 to 230 of about 765,176 (310)

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Pre-Cambrian origin of <i>envelope</i>-carrying retrotransposons in metazoans. [PDF]

Elife
Chary S, Hayashi R.
europepmc   +1 more source

Association and Age Heterogeneity of Systemic Metabolomic Signatures With Age-Related Cataract: A Mendelian Randomization and Heterogeneity Analysis. [PDF]

Transl Vis Sci Technol
Liu Z, Lu A, He S, Wang Y, Su G, Yang P.
europepmc   +1 more source

ON GLYCOPROTEINS

Journal of Biological Chemistry, 1937
Karl Meyer, John W. Palmer, Elizabeth M. Smyth   +2 more
openaire   +1 more source

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

Clear Positive MOG Antibodies in Adults With Multiple Sclerosis Features: Diagnostic Challenges. [PDF]

Neurol Neuroimmunol Neuroinflamm
Garcia J, Shor N, Boutiere C, Pique J, Boudot De La Motte M, Guillaume M, Delourme A, Zephir H, Ciron J, Carra-Dalliere C, Buissonnière P, Mélé N, Aboab J, Cohen M, Wang A, Couturier J, Rusu D, Thouvenot E, Laplaud DA, Ruet A, Bourre B, Durand-Dubief F, Benyahya L, Collongues N, Michel L, Deschamps R, Papeix C, Audoin B, Stankoff B, Touitou V, Vignal Clermont C, Sterlin D, Marignier R, Maillart E, NOMADMUS study group.   +34 more
europepmc   +1 more source

Artificial intelligence prediction of therapy response in newly diagnosed adult severe primary immune thrombocytopenia. [PDF]

Res Pract Thromb Haemost
Zhai X, Qi S, Wang X, Zhang W, Chen M, Shen Q, Gong X, Zhai W, Liu S, Liang X, Ma Y, Song Z, Gale RP, Wang J, Yang R, Liu X, Zhang L, Chen J.   +17 more
europepmc   +1 more source

Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients

Annals of Neurology, EarlyView.
Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer, Seth Frietze, Serena W.R. Lewis, Emily C. Artman, Christina Coughlan, Safa I. Vaseemuddin, Arianna Gentile Polese, Maria A. Nagel, Stephen K. Tyring, Fyona Okundia, Anthony J. Saviola, Gary C. Curhan, Sharon G. Curhan, Diego Restrepo, Andrew N. Bubak   +14 more
wiley   +1 more source

Association of Glycoprotein Acetylation With Carotid-Femoral Pulse Wave Velocity in Patients Receiving Maintenance Hemodialysis. [PDF]

Med Sci Monit
Su IM, Wang CH, Kuo CH, Lin YL, Liou HH, Hsu BG.   +5 more
europepmc   +1 more source

Serum Chitotriosidase Links to Activated Glia at Chronic Active Lesion Rims in Multiple Sclerosis Brain

Annals of Neurology, EarlyView.
Objective The objective of this study was to explore the association between 18 kDa translocator protein (TSPO)‐positron emission tomography (PET)–measurable glial activation and serum chitotriosidase (CHIT1) in people with multiple sclerosis (pwMS), and its expression in postmortem MS brain tissue.
Venla Ahola, Maija Saraste, Edoardo Pedrini, Joel Tuomaala, Luzia Buchholz, Markus Matilainen, Johanna Lindenberg, Eeva‐Christine Brockmann, Maria Sofia Martire, Sofia Sandgren, David Leppert, Jens Kuhle, Tanja Kuhlmann, Martina Absinta, Laura Airas   +14 more
wiley   +1 more source