Results 231 to 240 of about 955,216 (365)

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Development of an indirect ELISA for the detection of venezuelan equine encephalitis virus specific antibodies in horses. [PDF]

PLoS One
Chevrier M, Mathews-Martin L, Mariteragi-Helle T, Dumarest M, Boudjadi Y, Bréard E, Turpaud M, Deshayes T, Vissani MA, Vinueza RL, Coello Peralta R, Vanhomwegen J, Zientara S, Beck C, Martin-Latil S, Desprès P, Gonzalez G, Migné CV.   +17 more
europepmc   +1 more source

Chikungunya virus glycoprotein expression using recombinant baculoviruses

, 2011
Stefan Metz, Corinne Geertsema, J.M. Vlak, Gorben P. Pijlman   +3 more
openalex   +1 more source

Interference of ATP‐Binding Cassette Transporter by Functional Nano‐Delivery System for High Efficiency Management of Insecticide‐Resistant Nilaparvata lugens

Advanced Science, EarlyView.
A ZIF‐90 nanocarrier delivers dinotefuran and suppresses NlABCG3 and NlABCH1 in resistant Nilaparvata lugens. This system combines pH/ATP‐triggered release with enhanced foliar retention, improving efficacy while sparing honeybees and promoting rice growth, offering a promising resistance‐breaking strategy.
Chengshuai He, Hejun Ren, Shuo Zhang, Jikang Cheng, Hui Zhang, Jiao Liu, Sijie Wang, Congfen Gao, Yanchao Zhang, Yunhao Gao   +9 more
wiley   +1 more source

Tumor-directed evolution of VSVΔ51M produces novel viruses with enhanced antitumor efficacy. [PDF]

Front Mol Biosci
Albaradie OA, Moglan AM, Samman YM, Alsayegh FF, Alharbi HM, Almarghalani N, Alotaibi K, Jalal MM, Altayar MA, Saeedi NH, Niaz HA, Zakri S, Almuzaini A, Kaboha F, Alabbas SY, Albalawi YA, Alsofyani A, Pelin A, Alsayb MA, Damfo S, Mahmoud AB, Alkayyal AA.   +21 more
europepmc   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Platelet-Targeted Self-Amplifying mRNA for Safe, Long-Acting Thromboprophylaxis. [PDF]

Circ Res
Song Y, Nguyen TH, Shi P, Refaat A, Pham CV, Xu B, Ren S, Skoraczynski JI, Nguyen A, Liu H, Klesen A, Trépout S, Vidallon MLP, Peter K, Wang X.   +14 more
europepmc   +1 more source

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

Can Multiple Sclerosis be Managed Over a Lifetime? A Rare 72-Year Journey of Pediatric-Onset to Secondary Progressive Multiple Sclerosis. [PDF]

Clin Case Rep
Etemadifar M, Dehghani A, Rahimi M, Ghandehari A, Salari M.   +4 more
europepmc   +1 more source

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Journal of Clinical Investigation, 1995
A. Schinkel, E. Wagenaar, L. V. Deemter, C. A. Mol, P. Borst   +4 more
semanticscholar   +1 more source