Results 211 to 220 of about 469,301 (344)

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

A functionally tunable magnetic nanochains platform for N-glycoproteomic analysis of extracellular vesicles from ultratrace biofluids. [PDF]

Nat Commun
Li M, Song X, Tu H, Sun J, Deng Y, Wang B, Cai Y, Wang Y, Li B, Wang Y, Zhang X, Wei D, Yang X, Guo Y, Li X, Gu J, Ni J, Zhou Y, Gu Z, Xie Z, Li Y, Guo X.   +21 more
europepmc   +1 more source

Fragments of the V1/V2 domain of HIV-1 glycoprotein 120 engineered for improved binding to the broadly neutralizing PG9 antibody

, 2016
Javier F. Morales, Bin Yu, Gerardo Perez, Kathryn A. Mesa, David L. Alexander, Phillip W. Berman   +5 more
openalex   +2 more sources

Mutations in the HIV-1 envelope glycoprotein can broadly rescue blocks at multiple steps in the virus replication cycle [PDF]

, 2019
Rachel Van Duyne, Lillian S. Kuo, Phuong Pham, Ken Fujii, Eric O. Freed   +4 more
openalex   +1 more source

The role of sialic acid in determining the survival of glycoproteins in the circulation.

Journal of Biological Chemistry, 1971
A. Morell, G. Gregoriadis, I. Scheinberg, J. Hickman, G. Ashwell   +4 more
semanticscholar   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Comparative N-Glycoproteomics Reveals Subtype-Specific N-Glycosylation Signatures and Immune Associations in Cholangiocarcinoma. [PDF]

Mol Cell Proteomics
Xia Z, Gao L, Hu M, Li Y, Yu K, Jiang N, Gao L, Liu Y, Lu Y, Ren Y, Tian C, Lu Y, Zhang J, Yu H, Yue P, Lin Y, Zhang R, Gong Y, Meng W.   +18 more
europepmc   +1 more source

ON GLYCOPROTEINS

Journal of Biological Chemistry, 1936
Karl Meyer, John W. Palmer
openaire   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Combined effects of restriction factors and transduction adjuvants on lentiviral vector gene transfer efficacy. [PDF]

Sci Rep
Dewannieux M, Fofana F, Hamon K, Mormin M, Galy A.   +4 more
europepmc   +1 more source