Results 221 to 230 of about 244,382 (297)
Advanced Science, EarlyView.A compartmentalized joint‐on‐chip (JoC) platform is here developed, modelling the interactions between cartilage and synovium in osteoarthritis (OA). Using independent culture and mechanical/biochemical stimulation, the JoC revealed how inflammation and mechanical damage drive mutual tissue changes.
Cecilia Palma +6 more
wiley +1 more source
Construction and Characterization of a Vesicular Stomatitis Virus Chimera Expressing Schmallenberg Virus Glycoproteins. [PDF]
Vet SciGuo H +7 more
europepmc +1 more source
Advanced Science, EarlyView.The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi +15 more
wiley +1 more source
Differential melting voltage by tandem-trapped ion mobility spectrometry: glycan structure influences glycoprotein stability. [PDF]
RSC Chem BiolChai M, Bleiholder C, Liu FC.
europepmc +1 more source
A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing
Advanced Science, EarlyView.This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang +17 more
wiley +1 more source
Structural and Functional Hallmarks of Sindbis Virus Proteins: From Virion Architecture to Pathogenesis. [PDF]
Int J Mol SciGeng Q, Navaratnarajah CK, Zhang W.
europepmc +1 more source
Advanced Science, EarlyView.TBC1D22B, a Golgi‐localized RabGAP linked to poor prognosis in breast cancer, inhibits ER‐to‐Golgi transport via RAB1B inactivation. This disrupts secretion, drives oncogenic transcriptional reprogramming, and promotes tumor growth. These findings indicate that TBC1D22B connects membrane trafficking to transcriptional control and cancer progression ...
Flavia Martino +16 more
wiley +1 more source
Correction: Dual roles of Anisakis pegreffii proteins in macrophage immune dynamics
Frontiers in ImmunologyMin-hao Zeng +8 more
doaj +1 more source
Progress in Pseudotyping Lentiviral Vectors Towards Cell-Specific Gene Delivery In Vivo. [PDF]
VirusesArduini A, Katiyar H, Liang C.
europepmc +1 more source