Results 211 to 220 of about 238,504 (307)

A Bi‐Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging‐Related Metabolic Dysfunction

Advanced Science, EarlyView.
An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song, Xiaoxue Du, Wenbo Dong, Ying Wang, Xiaojing Wang, Qiliang Yin   +5 more
wiley   +1 more source

Intracellular Delivery of Hydrophilic Glycans Using Superchaotropic Clusters. [PDF]

Angew Chem Int Ed Engl
Tang Q, Ilie A, Gibson MI.
europepmc   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Antiviral activity of biogenic silver nanoparticles against HSV-1: integrating computational modeling and experimental validation. [PDF]

Iran J Microbiol
Soltani M, Elikaei A, Ghadam P, Ayadi Hassan S.   +3 more
europepmc   +1 more source

LFA‐1‐Engineered Extracellular Vesicles Deliver CD59 to Protect Endothelial Integrity in Acute Lung Injury

Advanced Science, EarlyView.
LFA‐1‐engineered extracellular vesicles preferentially target pulmonary endothelium and deliver CD59, thereby inhibiting membrane attack complex formation, preserving vascular integrity, and attenuating acute lung injury. This strategy reveals a targeted approach for protecting the pulmonary vasculature from complement‐mediated damage.
Yin Zhu, Shravani Etrouth, Payaningal R. Somanath, S. Priya Narayanan, Yutao Liu, Xiaoyun Wang, Duo Zhang   +6 more
wiley   +1 more source

Adapting in-cell ELISA to investigate the localization of hepatitis C virus envelope glycoproteins. [PDF]

Microbiol Spectr
Dimitriadis S, Edmans M, Frumento N, Hong Xiang N, Bailey J, Cox A, Klenerman P, Barnes E, Zurbia-Flores GM.   +8 more
europepmc   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Composition and Function of Decellularized Human Lung Extracellular Matrix from Congenital Pulmonary Airway Malformation. [PDF]

J Clin Med
Li Y, Yang P, Yuan M, Zhu X, Mao S, Yang Y, Yao M, Chen F, Zhou Y, Bao J, Xu C, Li Y.   +11 more
europepmc   +1 more source

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

Glycoprotein-induced phase separation drives unconventional secretion of galectin-3. [PDF]

Nat Commun
Zhao Z, He Z, Gu H, Zhou A, Wang Y, Liang Z, Geng J, Xu X, Wang M, Li C, Fan Y, Cheng H, Sun L, Mayo KH, Raz A, Tai G, Zhou Y.   +16 more
europepmc   +1 more source