Results 271 to 280 of about 604,492 (391)

Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

Advanced Science, EarlyView.
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian, Jinxiang Wang, Qiji Li, Yangruiyu Liu, Yanping Chen, Jiacheng Feng, Zi‐Ning Lei, Harsh Patel, Chao‐Yun Cai, Yuzhi Xu, Chuntao Quan, Lingyan Fei, Zexiu Xiao, Shuo Fang, Tianxin Lin, Zhe‐Sheng Chen, Yuchen Liu, Leli Zeng, Yihang Pan   +18 more
wiley   +1 more source

Deciphering the Metabolic Impact and Clinical Relevance of N-Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling. [PDF]

Adv Sci (Weinh)
Liu G, Chen L, Zhao J, Jiang Y, Guo Y, Mao X, Ren X, Liu K, Mei Q, Li Q, Huang H.   +10 more
europepmc   +1 more source

The Cleavage of Human α1-Acid Glycoprotein by Pepsin

, 1960
Herbert Weinfeld, Marvin Tunis
openalex   +1 more source

Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins

Nature Biotechnology, 2010
Darius Ghaderi, Rachel E. Taylor, V. Padler-Karavani, S. Diaz, A. Varki   +4 more
semanticscholar   +1 more source

Compressed Cells Facilitate Adhesion Through Glycocalyx

Advanced Science, EarlyView.
This study quantifies how cell compression and confinement triggers cell adhesion. Under low compression, integrins dominate cell adhesion to extracellular matrix (ECM) proteins, whereas the glycocalyx contributes weak unspecific adhesion. With increasing compression, the glycocalyx increases its unspecific adhesion to ECM and non‐ECM proteins and can ...
Xiaole Wang, Jonne Helenius, Daniel J. Müller, Nico Strohmeyer   +3 more
wiley   +1 more source

Mass Spectrometric Analysis of Antigenic Determinant Glycans of Soybean Glycoprotein Gly m Bd 30K. [PDF]

Molecules
Li L, Luo S, Wu Y, Feng X, Ding Y, Zhou Y.   +5 more
europepmc   +1 more source

High-efficiency labeling of sialylated glycoproteins on living cells

Nature Methods, 2009
Ying Zeng, T.N.C. Ramya, A. Dirksen, P. Dawson, J. Paulson   +4 more
semanticscholar   +1 more source

Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

Advanced Science, EarlyView.
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo, Yuce Peng, Guozhi Zhao, Zhesheng Cheng, Minghao Luo, Dingyi Lv, Shuting Chang, Na Li, Yanyao Huang, Xunjia Li, An He   +10 more
wiley   +1 more source

Tailored translation: Local tRNA activation to match protein composition needs. [PDF]

Plant Cell
Arribas-Hernández L.
europepmc   +1 more source

D‐glucuronyl C5‐Epimerase Binds to EGFR to Suppress Kidney Fibrosis

Advanced Science, EarlyView.
Glucuronyl C5‐epimerase (Hsepi, gene name Glce) is a key enzyme catalyzing heparan sulfate (HS) chain biosynthesis in HS proteoglycans, which are ubiquitously expressed on cell membranes. In normal renal tubular cells, Glce binds to the intracellular domains of EGFR, maintaining stable and orderly EGFR phosphorylation.
Xiaoqi Jing, Jun Wu, Jingru Ning, Xiaoyu Ding, Zhenyun Du, Xiaojiang Wang, Lulin Huang, Ran Wang, Changlin Mei, Kan Ding   +9 more
wiley   +1 more source