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Sulfotransferases in glycosaminoglycan biosynthesis
Current Opinion in Structural Biology, 2003Most of the sulfotransferases participating in glycosaminoglycan biosynthesis have now been identified. Their essential role in generating binding sites for proteins interacting with glycosaminoglycans is apparent. These interactions may influence important biological processes such as growth control, signal transduction, cell adhesion and lipid ...
Marion Kusche-Gullberg, Lena Kjellén
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2010
Publisher Summary Glycosaminoglycans (GAGs) are a family of highly sulfated, complex, polydisperse linear polysaccharides that display a variety of important biological roles. Based on the difference of repeating disaccharide units comprising GAGs, they can be categorized into four main groups: heparin/heparan sulfate, chondroitin sulfate/dermatan ...
Zhenqing Zhang +2 more
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Publisher Summary Glycosaminoglycans (GAGs) are a family of highly sulfated, complex, polydisperse linear polysaccharides that display a variety of important biological roles. Based on the difference of repeating disaccharide units comprising GAGs, they can be categorized into four main groups: heparin/heparan sulfate, chondroitin sulfate/dermatan ...
Zhenqing Zhang +2 more
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Biomedical Chromatography, 2002
AbstractGlycosaminoglycans are a family of polydisperse, highly sulfated complex mixtures of linear polysaccharides that are involved in many life processes. Defining the structure of glycosaminoglycans is an important factor in elucidating their structure–activity relationship.
Wenjun Mao +2 more
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AbstractGlycosaminoglycans are a family of polydisperse, highly sulfated complex mixtures of linear polysaccharides that are involved in many life processes. Defining the structure of glycosaminoglycans is an important factor in elucidating their structure–activity relationship.
Wenjun Mao +2 more
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Serpin–Glycosaminoglycan Interactions
2011Serpins (serine protease inhibitors) have traditionally been grouped together based on structural homology. They share common structural features of primary sequence, but not all serpins require binding to cofactors in order to achieve maximal protease inhibition. In order to obtain physiologically relevant rates of inhibition of target proteases, some
Chantelle M. Rein +2 more
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The glycosaminoglycans of open wounds
Journal of Surgical Research, 1980Abstract Histochemical methods and selective enzymatic digestions were used to study the time course and location of specific glycosaminoglycans in open rabbit wounds. Hyaluronic acid seems to be increased in whole edge tissue, which may account for wound contraction and epithelial migration.
R. Bruce Donoff, Stanley A. Alexander
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Glycosaminoglycans in lung carcinoma
Human Pathology, 1988In order to better understand the chemical composition of carcinomas of the lung, glycosaminoglycans (GAGs) of lung tumors from 34 patients were studied histochemically and quantitated spectrophotometrically. When the GAG quantity in neoplastic tissue was compared with that in normal lung tissue, total GAG contents in various carcinomas of the lung ...
Minoru Suzuki +2 more
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Glycosaminoglycans and mucopolysaccharidoses
1996Item does not contain ...
Jong, J.G.N. de +4 more
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Glycosaminoglycans in human diabetes.
Diabete & metabolisme, 1983The serum concentrations of different glycosaminoglycan fractions have been studied in diabetic subjects without evidence of vascular complications and compared with those of age-and sex-matched normal subjects. Electrophoretic analysis of the various glycosaminoglycan fractions showed an increase in hyalunoric acid and heparin, and a decrease in ...
CERIELLO A +5 more
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The Biosynthesis of Glycosaminoglycans
Biochemical Society Transactions, 1973The sites of nucleotide conjugation are few. Two pyrophosphorylase reactions are sufficient to account for the occurrence of the variety of sugar nucleotides previously cited. The pathways for each are different. Whereas UDP-glucose arises from a direct conjugation of glucose 1-phosphate with UTP by a pyrophosphorylase whose specificity has been ...
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Cytokines and Glycosaminoglycans (GAGS)
2003Glycosaminoglycans (GAGs), formerly known as mucopolysaccharides, are anionic polysaccharide molecules that are widely distributed among animal tissues and produced by most cell types. Several key immune cytokines have been shown to bind strongly and selectively to these molecules resulting in modulation of their bioactivity and/or tissue distribution.
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