Results 91 to 100 of about 174,463 (312)

High-Throughput Virtual Screening of 4487 flavonoids: New insights on the structural inhibition of SARS-CoV-2 Main Protease [PDF]

arXiv, 2020
COVID-19 presents a great threat to public health worldwide and the infectious agent SARS-CoV-2 is currently the target of much research aiming at inhibition. The virus' main protease is a dimeric enzyme that has only recently begun to be thoroughly described, opening the door for virtual screening more broadly. Here, a PAIN-filtered flavonoid database
arxiv  

Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials

BMEMat, EarlyView.
Smart biomaterials are rapidly emerging as tools for tissue engineering, and artificial intelligence has played essential roles in biomaterial studies. By bridging the literature gap in AI‐based design, synthesis and analysis of smart biomaterials, the current review shares perspectives on how biomaterial scientists can practically incorporate AI for ...
Pengfei Jiang, Yefei Dai, Yujun Hou, Joshua Stein, Shichen Steven Lin, Chaochen Zhou, Yannan Hou, Rongrong Zhu, Ki‐Bum Lee, Letao Yang   +9 more
wiley   +1 more source

Hierarchical hydropathic evolution of influenza glycoproteins (N2, H3, A/H3N2) under relentless vaccination pressure [PDF]

arXiv, 2013
Hemagglutinin (HA) and neuraminidase (NA) are highly variable envelope glycoproteins. Here hydropathic analysis, previously applied to quantify common flu (H1N1) evolution (1934-), is applied to the evolution of less common but more virulent (avian derived) H3N2 (1968-), beginning with N2.
arxiv  

Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity Pair*

Journal of Biological Chemistry, 2013
Background: The bacterial type VI secretion system (T6SS) translocates toxic effector proteins into target cells. Results: Novel T6S peptidoglycan glycoside hydrolase effector-immunity families are identified and a representative pair is structurally and
J. Whitney, Seemay Chou, Alistair B. Russell, J. Biboy, Taylor E. Gardiner, Michael A. Ferrin, M. Brittnacher, W. Vollmer, J. D. Mougous   +8 more
semanticscholar   +1 more source

Breaking barriers: Smart vaccine platforms for cancer immunomodulation

Cancer Communications, EarlyView.
Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines. Leveraging the immune system's natural ability to target and kill cancer cells holds great therapeutic potential ...
Mohammad Mahmoudi Gomari, Taha Ghantabpour, Nima Pourgholam, Neda Rostami, Stephen M. Hatfield, Farzaneh Namazifar, Shadi Abkhiz, Seyed Sadegh Eslami, Mahsa Ramezanpour, Mahsa Darestanifarahani, Igor Astsaturov, Sidi A. Bencherif    +11 more
wiley   +1 more source

Resolving solution conformations of the model semi-flexible polyelectrolyte homogalacturonan using molecular dynamics simulations and small-angle x-ray scattering [PDF]

arXiv, 2018
The conformation of polyelectrolytes in the solution state has long been of interest in polymer science. Herein we utilize all atom molecular dynamics simulations (MD) and small-angle x-ray scattering experiments (SAXS) to elucidate the molecular structure of the model polyelectrolyte homogalacturonan. Several degrees of polymerization were studied and
arxiv  

Thermostable glycoside hydrolases in Biorefining

, 2014
Glycoside hydrolases, which are responsible for the degradation of the major fraction of biomass, the polymeric carbohydrates in starch and lignocellulose, are predicted to gain increasing roles as catalysts in biorefining applications in the future ...
Javier A. Linares-Pastén, M. Andersson, E. Karlsson   +2 more
semanticscholar   +1 more source

Phytochemical Profile and Anticancer Activity of Achillea conferta Leaf Extracts: Insights Into Antioxidant Properties

Chemistry &Biodiversity, EarlyView.
ABSTRACT This study explores the phytochemical composition and biological potential of extracts from Achillea conferta leaves, specifically hydroethanolic extract (HE), total flavonoid extract (TFE), and glycoside flavonoid extract (GFE). Phytochemical screening of HE revealed significant concentrations of phenolic compounds, flavonoids, and tannins ...
Mhmood Shakoori Yaseen, Rafah Razooq Hameed Al‐Samarrai, Mohamed Bouaziz, Sami Zouari   +3 more
wiley   +1 more source

Role of Glycoside Phosphorylases in Mannose Foraging by Human Gut Bacteria*

Journal of Biological Chemistry, 2013
Background: The relations between the gut microbiota, food, and host play a crucial role in human health. Results: Prevalent bacterial glycoside phosphorylases are able to break down dietary carbohydrates and the N-glycans lining the intestinal ...
S. Ladevèze, Laurence Tarquis, D. Cecchini, J. Bercovici, I. André, C. Topham, S. Morel, É. Laville, P. Monsan, V. Lombard, B. Henrissat, G. Potocki-Veronese   +11 more
semanticscholar   +1 more source

Green Propolis Extract‐Mediated Synthesis of Biogenic Silver Nanoparticles: In vitro Antileishmanial and Antibacterial Activities, Cytotoxicity and Ex vivo Irritation Testing

Chemistry &Biodiversity, Accepted Article.
This study describes the green synthesis, characterization, and biological evaluation of silver nanoparticles (AgNPs) obtained from green propolis (AgNPs‐PRO). Prior to nanoparticles synthesis, a hydroethanolic green propolis extract (GPE) was obtained through Ultrasound Assisted Extraction, and characterized by High Performance Liquid Chromatography ...
Erica Tirzah S. Lima, Victoria L. S. Santos, Wanessa J. S. Mota, Frederico S. Martins, Ricardo L. C. de Albuquerque-Junior, André L. S. Santos, Simone S. C. Oliveira, Jéssica A. de Lima, Adriana de Jesus Santos, Cochiran P. dos Santos, Sona Jain, Eliana B. Souto, Juliana C. Cardoso, Patrícia Severino   +13 more
wiley   +1 more source