Results 21 to 30 of about 174,463 (312)
Nature Communications, 2018 Activation of innate immunity by membrane-localized receptors is conserved across eukaryotes. Plant genomes contain hundreds of such receptor-like genes and those encoding proteins with an extracellular leucine-rich repeat (LRR) domain represent the ...
Yan Wang +11 more
semanticscholar +1 more source
Synthesis, antimicrobial and cytotoxicity evaluation of new cholesterol congeners
Beilstein Journal of Organic Chemistry, 2015 3β-Azidocholest-5-ene (3) and (3β)-3-(prop-2-yn-1-yloxy)cholest-5-ene (10) were prepared as substrates to synthesize a variety of three-motif pharmacophoric conjugates through CuAAC.
Mohamed Ramadan El Sayed Aly +2 more
doaj +1 more source
Antibodies, 2018 Antibody-drug conjugates (ADCs) offer a combination of antibody therapy and specific delivery of potent small-molecule payloads to target cells. The properties of the ADC molecule are determined by the balance of its components.
Tero Satomaa +9 more
doaj +1 more source
Free and Glycosidically Bound Volatile Compounds in Okinawan Pineapple (Ananas comosus)
Applied Sciences, 2022 Fruit plants produce various volatile compounds that emit distinct aroma characteristics and contribute to their flavor qualities. However, some of these substances, especially hydroxyl-group molecules, are in non-volatile glycosylated forms.
Yonathan Asikin +6 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2013 Clean deprotection of carbohydrate derivatives containing benzylidene acetals and benzyl ethers was achieved under catalytic transfer hydrogenation conditions by using a combination of triethylsilane and 10% Pd/C in CH3OH at room temperature.
Abhishek Santra +2 more
doaj +1 more source
Conformational free energies of methyl-$α$-L-iduronic and methyl-$β$-D-glucuronic acids in water [PDF]
J. Chem. Phys. 132, 104108 (2010), 2009 We present a simulation protocol that allows for efficient sampling of the degrees of freedom of a solute in explicit solvent. The protocol involves using a non-equilibrium umbrella sampling method, in this case the recently developed adaptively biased molecular dynamics method, to compute an approximate free energy for the slow modes of the solute in ...
arxiv +1 more source
The Journal of pharmacy and pharmacology, 2019 Paeoniflorin, a representative pinane monoterpene glycoside in plants of Paeoniaceae family, possesses promising anticancer activities on diverse tumours.
Yongjing Xiang +5 more
semanticscholar +1 more source
Molecules, 2019 Glycosylated flavanols (monoglycosides and diglycosides) in skin and seed extracts of Vitis vinifera grapes grown in Castilla-La Mancha (Spain) were investigated using ultra-high-performance liquid chromatography—tandem mass spectrometry (UHPLC-ESI-
José Pérez-Navarro +5 more
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Molecules, 2012 A facile, convenient and high yielding synthesis of novel <em>S</em>-glycosides and <em>N</em>-glycosides incorporating 1,2,3,4-tetrahydronaphthalene and or 1,2-dihydropyridines moieties has been described. The aglycons <strong&
Maha S. Al-Mutairi +4 more
doaj +1 more source
A nucleobase-centered coarse-grained representation for structure prediction of RNA motifs [PDF]
Nucleic Acids Res. 46, 1674 (2018), 2017 We introduce the SPlit-and-conQueR (SPQR) model, a coarse-grained representation of RNA designed for structure prediction and refinement. In our approach, the representation of a nucleotide consists of a point particle for the phosphate group and an anisotropic particle for the nucleoside.
arxiv +1 more source