Crystal Structure of Thermotoga maritima α-Glucosidase AglA Defines a New Clan of NAD+-dependent Glycosidases [PDF]
, 2003 Glycoside hydrolase family 4 represents an unusual group of glucosidases with a requirement for NAD(+), divalent metal cations, and reducing conditions. The family is also unique in its inclusion of both alpha- and beta-specific enzymes.
Hoffmann, Volker +4 more
core +2 more sources
Cardiac Glycosides and Cardiomyopathy [PDF]
Hypertension, 2006 Digitalis-like steroids and related agents have been a mainstay in the treatment of congestive heart failure ever since the publication, in 1785, of Withering’s seminal monograph on foxglove. Heart failure refers to the clinical syndrome that results when the heart is unable to pump sufficient blood to keep up with the metabolic demands of the body ...
MANUNTA , PAOLO, FERRANDI M.
openaire +4 more sources
Marine Carbohydrate-Based Compounds with Medicinal Properties
Marine Drugs, 2018 The oceans harbor a great diversity of organisms, and have been recognized as an important source of new compounds with nutritional and therapeutic potential.
Ariana A. Vasconcelos, Vitor H. Pomin
doaj +1 more source
A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors
Molecules, 2022 Cdc25 phosphatases have been considered promising targets for anticancer development due to the correlation of their overexpression with a wide variety of cancers.
Ahmed Bakr Abdelwahab +4 more
doaj +1 more source
In the Search of Glycoside-Based Molecules as Antidiabetic Agents
Topics in current chemistry, 2019 This review is an effort to summarize recent developments in synthesis of O-glycosides and N-, C-glycosyl molecules with promising antidiabetic potential. Articles published after 2000 are included.
A. Pałasz +5 more
semanticscholar +1 more source
Mutations in UDP-Glucose:Sterol Glucosyltransferase in Arabidopsis Cause Transparent Testa Phenotype and Suberization Defect in Seeds [PDF]
, 2009 In higher plants, the most abundant sterol derivatives are steryl glycosides (SGs) and acyl SGs. Arabidopsis (Arabidopsis thaliana) contains two genes, UGT80A2 and UGT80B1, that encode UDP-Glc:sterol glycosyltransferases, enzymes that catalyze the ...
Auer, Manfred +14 more
core +5 more sources
Complementary Metagenomic Approaches Improve Reconstruction of Microbial Diversity in a Forest Soil. [PDF]
, 2020 Soil ecosystems harbor diverse microorganisms and yet remain only partially characterized as neither single-cell sequencing nor whole-community sequencing offers a complete picture of these complex communities.
Alteio, LV +12 more
core +3 more sources
New triterpenic compounds from Swertia chirata
Ancient Science of Life, 2017 Aim: To study the Phytochemical constituents of dried aerial parts of Swertia chirata Linn (family Gentianaceae). Methods: The ethanolic extract of the aerial parts of plant S.
Sakshi Bajaj +2 more
doaj +1 more source
Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases. [PDF]
, 2015 MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a
Cao, Sheng +6 more
core +2 more sources
Flavonoid Glycosides from Endemic Bulgarian Astragalus aitosensis (Ivanisch.)
Molecules, 2019 Astragalus is a very interesting plant genus, well-known for its content of flavonoids, triterpenes and polysaccharides. Its secondary metabolites are described as biologically active compounds showing several activities, e.g., immunomodulating ...
Hristo Vasilev +6 more
doaj +1 more source