Results 101 to 110 of about 23,307 (259)

A new group of glycoside hydrolase family 13 α-amylases with an aberrant catalytic triad [PDF]

, 2017
α-Amylases are glycoside hydrolase enzymes that act on the α(1→4) glycosidic linkages in glycogen, starch, and related α-glucans, and are ubiquitously present in Nature. Most α-amylases have been classified in glycoside hydrolase family 13 with a typical
null Ihsanawati, Ocky K. Radjasa, Dessy Natalia, Ihsanawati,, Fean D. Sarian, Zeily Nurachman, Radjasa, Ocky K, Marc J. E. C. van der Maarel, Sarian, Fean D, Dijkhuizen, Lubbert, Janeček, Štefan, Tjaard Pijning, Dijkhuizen, Lubbert; id_orcid, Lubbert Dijkhuizen, Pijning, Tjaard; id_orcid, van der Maarel, Marc J E C, Pijning, Tjaard, Natalia, Dessy, Štefan Janeček, Ihsanawati, Nurachman, Zeily   +20 more
core   +1 more source

Amylolytic glycoside hydrolases [PDF]

Cellular and Molecular Life Sciences, 2016
Štefan, Janeček, Birte, Svensson
openaire   +2 more sources

Functional and transcriptomic analyses in Neurospora crassa reveal a crucial role for the N‐glycoprotein deglycosylation process in fungal homeostasis

The FEBS Journal, EarlyView.
In Neurospora crassa, a cytosolic GH18 endo‐β‐n‐acetylglucosaminidase (ENGase) functions as an active deglycosylating enzyme. Deletion of this severely alters tolerance to multiple stress conditions and causes extensive transcriptomic reprogramming, including upregulation of a GH20 exo‐β‐n‐acetylhexosaminidase under ER stress, indicating that N. crassa
Anastasios Samaras, Tanim Jabid Hossain, Magnus Karlsson, Georgios Tzelepis   +3 more
wiley   +1 more source

First glycoside hydrolase family 2 enzymes from Thermus antranikianii and Thermus brockianus with β-glucosidase activity

Frontiers in Bioengineering and Biotechnology, 2015
Two genes tagh2 and tbgh2 coding for enzymes with hydrolytic activity towards esculin were identified from the extreme thermophilic, aerobic bacteria Thermus antranikianii (Ta) and T. brockianus (Tb). Shortened conserved domains predicted a membership of
Carola eSchröder, Saskia eBlank, Garabed eAntranikian   +2 more
doaj   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion [PDF]

, 2012
SummaryNagZ is a glycoside hydrolase that participates in peptidoglycan (PG) recycling by removing β-N-acetylglucosamine from PG fragments that are excised from the bacterial cell wall during growth.
Whitworth, Garrett E., Bacik, John-Paul, Stubbs, Keith A., Mark, Brian L., Vocadlo, David J.   +4 more
core   +1 more source

Impact of ginsenoside Rb1 on gut microbiome and associated changes in pharmacokinetics in rats

Scientific Reports
Ginsenoside Rb1 exhibits a wide range of biological activities, and gut microbiota is considered the main metabolic site for Rb1. However, the impact of gut microbiota on the pharmacokinetics of Rb1 are still uncertain. In this study, we investigated the
Yue Chen, Kang-xi Zhang, Hui Liu, Yue Zhu, Qing-yun Bu, Shu-xia Song, Ya-chun Li, Hong Zou, Xiao-yan You, Guo-ping Zhao   +9 more
doaj   +1 more source

Acarbose impairs gut Bacteroides growth by targeting intracellular glucosidases

mBio
Acarbose is a type 2 diabetes medicine that prevents dietary starch breakdown into glucose by inhibiting host amylase and glucosidase enzymes. Numerous gut species in the Bacteroides genus enzymatically break down starch and change in relative abundance ...
Haley A. Brown, Adeline L. Morris, Nicholas A. Pudlo, Ashley E. Hopkins, Eric C. Martens, Jonathan L. Golob, Nicole M. Koropatkin   +6 more
doaj   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

Δ^11,12 Double Bond Formation in Tirandamycin Biosynthesis is Atypically Catalyzed by TrdE, a Glycoside Hydrolase Family Enzyme [PDF]

, 2016
The tirandamycins (TAMs) are a small group of Streptomyces-derived natural products that target bacterial RNA polymerase. Within the TAM biosynthetic cluster, trdE encodes a glycoside hydrolase whose role in TAM biosynthesis has been undefined until now.
Bo Wang (86769), Changsheng Zhang (1450165), Xuhua Mo (1677100), Si Zhang (111568), Yongxiang Song (1613077), Junying Ma (466656), Hongbo Huang (773075), Jianhua Ju (773073)   +7 more
core   +1 more source