Results 91 to 100 of about 69,901 (250)

Zwitterionic pyrrolidene-phosphonates: inhibitors of the glycoside hydrolase-like phosphorylase Streptomyces coelicolor GlgEI-V279S

, 2017
We synthesized and evaluated new zwitterionic inhibitors against glycoside hydrolase-like phosphorylaseStreptomyces coelicolor(Sco) GlgEI-V279S which plays a role in α-glucan biosynthesis.
Sri Kumar Veleti, Donald R. Ronning, Cecile Petit, Steven J. Sucheck   +3 more
core   +1 more source

Gut Microbiota Analysis and Comparison in Forest Musk Deer (Moschus berezovskii) of Different Ages and Musk‐Secreting Periods

Integrative Zoology, EarlyView.
Metagenomic sequencing was used to analyze fecal microbiota of captive male forest musk deer (FMD) from the Sichuan Institute of Musk Deer Breeding across ages and musk‐secreting periods. Gut microbiota was generally stable and dominated by Firmicutes, while age and musk secretion shaped microbial composition and function, with musk collection linked ...
Jiuyan Jiang, Qiuping Huang, Fei Wu, Pingwei Liang, Linping Fan, Xia Zhou, Chengli Zheng, Xin Shi, Huina Song, Ji Wang, Jing Xue Luo, Ji Chen, Qinlin Yang, Siqi Peng, Lingqian Yin, Dejun Zeng, Hang Jie, Guangxiang Zhu   +17 more
wiley   +1 more source

First glycoside hydrolase family 2 enzymes from Thermus antranikianii and Thermus brockianus with β-glucosidase activity

Frontiers in Bioengineering and Biotechnology, 2015
Two genes tagh2 and tbgh2 coding for enzymes with hydrolytic activity towards esculin were identified from the extreme thermophilic, aerobic bacteria Thermus antranikianii (Ta) and T. brockianus (Tb). Shortened conserved domains predicted a membership of
Carola eSchröder, Saskia eBlank, Garabed eAntranikian   +2 more
doaj   +1 more source

Structural and thermodynamic analyses of a novel β‐1,2‐glucan binding mode in the ABC transporter solute‐binding protein Chy400_4166 from Chloroflexus aurantiacus

The FEBS Journal, EarlyView.
Cyclic β‐1,2‐glucan (CβG)‐associated solute‐binding protein of type I ABC transporter was originally identified in Chloroflexus aurantiacus, a phototrophic bacterium. Crystal structures in complex with CβGs revealed unique binding modes that are fundamentally distinct from that of the short β‐1,2‐glucooligosaccharides‐binding protein.
Kazuya Kato, Tatsuya Kaneko, Rintaro Hirayama, Nobukiyo Tanaka, Hiroyuki Nakai, Hidetaka Torigoe, Masahiro Nakajima   +6 more
wiley   +1 more source

Impact of ginsenoside Rb1 on gut microbiome and associated changes in pharmacokinetics in rats

Scientific Reports
Ginsenoside Rb1 exhibits a wide range of biological activities, and gut microbiota is considered the main metabolic site for Rb1. However, the impact of gut microbiota on the pharmacokinetics of Rb1 are still uncertain. In this study, we investigated the
Yue Chen, Kang-xi Zhang, Hui Liu, Yue Zhu, Qing-yun Bu, Shu-xia Song, Ya-chun Li, Hong Zou, Xiao-yan You, Guo-ping Zhao   +9 more
doaj   +1 more source

Acarbose impairs gut Bacteroides growth by targeting intracellular glucosidases

mBio
Acarbose is a type 2 diabetes medicine that prevents dietary starch breakdown into glucose by inhibiting host amylase and glucosidase enzymes. Numerous gut species in the Bacteroides genus enzymatically break down starch and change in relative abundance ...
Haley A. Brown, Adeline L. Morris, Nicholas A. Pudlo, Ashley E. Hopkins, Eric C. Martens, Jonathan L. Golob, Nicole M. Koropatkin   +6 more
doaj   +1 more source

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

The FEBS Journal, EarlyView.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti, Andre Schutzer Godoy, Caio Cesar Mello Capetti, Rafaela Sachetto Fernandes, Vanessa O. A. Pellegrini, Ornella M. Ontañon, Eleonora Campos, Rodrigo V. Portugal, Igor Polikarpov   +8 more
wiley   +1 more source

Amylolytic glycoside hydrolases [PDF]

Cellular and Molecular Life Sciences, 2016
Štefan, Janeček, Birte, Svensson
openaire   +2 more sources

Functional and transcriptomic analyses in Neurospora crassa reveal a crucial role for the N‐glycoprotein deglycosylation process in fungal homeostasis

The FEBS Journal, EarlyView.
In Neurospora crassa, a cytosolic GH18 endo‐β‐n‐acetylglucosaminidase (ENGase) functions as an active deglycosylating enzyme. Deletion of this severely alters tolerance to multiple stress conditions and causes extensive transcriptomic reprogramming, including upregulation of a GH20 exo‐β‐n‐acetylhexosaminidase under ER stress, indicating that N. crassa
Anastasios Samaras, Tanim Jabid Hossain, Magnus Karlsson, Georgios Tzelepis   +3 more
wiley   +1 more source

Glycoside Hydrolases across Environmental Microbial Communities

PLOS Computational Biology, 2016
Across many environments microbial glycoside hydrolases support the enzymatic processing of carbohydrates, a critical function in many ecosystems. Little is known about how the microbial composition of a community and the potential for carbohydrate processing relate to each other.
Renaud Berlemont, Adam C. Martiny
openaire   +6 more sources