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Glycoside hydrolases: Catalytic base/nucleophile diversity
Biotechnology and Bioengineering, 2010AbstractRecent studies have shown that a number of glycoside hydrolase families do not follow the classical catalytic mechanisms, as they lack a typical catalytic base/nucleophile. A variety of mechanisms are used to replace this function, including substrate‐assisted catalysis, a network of several residues, and the use of non‐carboxylate residues or ...
Thu V, Vuong, David B, Wilson
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Structural and sequence-based classification of glycoside hydrolases
Current Opinion in Structural Biology, 1997The diversity of oligo- and polysaccharides provides an abundance of biological roles for these carbohydrates. The enzymes hydrolysing these compounds, the glycoside hydrolases, therefore mediate a wealth of biological functions. Glycoside hydrolases fall into a number of sequence-based families.
Henrissat, Bernard, Davies, G.
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Biotechnology Advances, 2018
Glycoside hydrolase family 20 β-N-acetyl-d-hexosaminidases (GH20s) catalyze the hydrolysis of glycosidic linkages in glycans, glycoproteins and glycolipids.
Tian Liu, Yanwei Duan, Q. Yang
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Glycoside hydrolase family 20 β-N-acetyl-d-hexosaminidases (GH20s) catalyze the hydrolysis of glycosidic linkages in glycans, glycoproteins and glycolipids.
Tian Liu, Yanwei Duan, Q. Yang
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Insight into the Thermophilic Mechanism of a Glycoside Hydrolase Family 5 β-Mannanase.
Journal of Agricultural and Food Chemistry, 2018To study the molecular basis for thermophilic β-mannanase of glycoside hydrolase family 5, two β-mannanases, TlMan5A and PMan5A, from Talaromyces leycettanus JCM12802 and Penicillium sp. WN1 were used as models.
Weina Liu +9 more
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Biocatalysis and Biotransformation, 2006
The glycoside hydrolases are a large group of enzymes that can be grouped into two major mechanistic classes based upon the stereochemical outcome of catalysis: retention and inversion of sugar anomeric configuration. Both mechanisms involve nucleophilic displacement at the anomeric center, and both proceed via positively charged oxocarbenium ion-like ...
Vivian L Y. Yip, Stephen G. Withers
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The glycoside hydrolases are a large group of enzymes that can be grouped into two major mechanistic classes based upon the stereochemical outcome of catalysis: retention and inversion of sugar anomeric configuration. Both mechanisms involve nucleophilic displacement at the anomeric center, and both proceed via positively charged oxocarbenium ion-like ...
Vivian L Y. Yip, Stephen G. Withers
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Glycoside hydrolases and glycosyltransferases: families and functional modules
Current Opinion in Structural Biology, 2001The past year has witnessed the expected increase in the number of solved structures of glycoside hydrolases and glycosyltransferases, and their constitutive modules. These structures show that, while glycoside hydrolases display an extraordinary variety of folds, glycosyltransferases and carbohydrate-binding modules appear to belong to a much smaller ...
Y, Bourne, B, Henrissat
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Plant receptor-like protein activation by a microbial glycoside hydrolase
Nature, 2022Yue Sun +11 more
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Modeling catalytic reaction mechanisms in glycoside hydrolases
Current Opinion in Chemical Biology, 2019Modeling catalysis in carbohydrate-active enzymes is a daunting challenge because of the high flexibility and diversity of both enzymes and carbohydrates. Glycoside hydrolases (GHs) are an illustrative example, where conformational changes and subtle interactions have been shown to be critical for catalysis.
Joan, Coines +2 more
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A GLYCOSIDE-HYDROLASE INHIBITOR IN TREATMENT OF DUMPING SYNDROME
The Lancet, 1979BAY g 5421, a glycoside-hydrolase inhibitor, produced symptomatic improvement in ten patients with the dumping syndrome. 100 mg BAY g 5421, given before a 50 g sucrose meal, produced pronounced attenuation of both hyperglycaemic and hypoglycaemic phases of plasma glucose levels; and it greatly reduced the rise in plasma levels of gastric inhibitory ...
J C, McLoughlin +2 more
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Purification of some glycoside hydrolases by affinity chromatography
Carbohydrate Research, 1977Two glycoproteins have been isolated from the cell walls of baker's yeast. One is a glucan-protein complex which has been partially characterised as having a branched carbohydrate structure composed of chains of (1 leads to 3)-linked beta-D-glucosyl residues, some of which are attached by (1 leads to 6)-linkages to the main chain.
M, Edward, R J, Sturgeon
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