Results 61 to 70 of about 69,901 (250)

Selective Isolation of Bifidobacterium From Human Faeces Using Pangenomics, Metagenomics, and Enzymology

Frontiers in Microbiology, 2021
Bifidobacterium, an important genus for human health, is difficult to isolate. We applied metagenomics, pangenomics, and enzymology to determine the dominant glycoside hydrolase (GH) families of Bifidobacterium and designed selective medium for ...
Shuanghong Yang, Shuanghong Yang, Xinqiang Xie, Jun Ma, Xingxiang He, Ying Li, Mingzhu Du, Mingzhu Du, Longyan Li, Lingshuang Yang, Qingping Wu, Wei Chen, Jumei Zhang   +12 more
doaj   +1 more source

Biochemical Studies and Production Optimization of β‐Glucosidase From Microcystis aeruginosa CACIAM 03 Using Organic Waste

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Global warming and industrial pollutants pose significant threats to environmental sustainability. In response, enzymes have emerged as promising tools for mitigating pollution. Enzymatic hydrolysis is considered environmentally sustainable due to its biological nature.
Gustavo Marques Serra, Matheus Silva da Fonseca Diniz, Evonnildo Costa Gonçalves, Agenor Valadares Santos, Luciana Pereira Xavier   +4 more
wiley   +1 more source

Computational Studies of Glycoside, Carboxylic Ester, and Thioester Hydrolase Mechanisms: A Review

, 2015
This article is a review of computational work over the last ∼15 years to elucidate the catalytic mechanisms of three major enzyme classes: glycoside hydrolases, carboxylic ester hydrolases, and thioesterases.
Carme Rovira (1275285), Peter J. Reilly (1499431)   +1 more
core   +1 more source

Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence

npj Biofilms and Microbiomes, 2023
Pel exopolysaccharide biosynthetic loci are phylogenetically widespread biofilm matrix determinants in bacteria. In Pseudomonas aeruginosa, Pel is crucial for cell-to-cell interactions and reducing susceptibility to antibiotic and mucolytic treatments ...
Erum Razvi, Gregory B. Whitfield, Courtney Reichhardt, Julia E. Dreifus, Alexandra R. Willis, Oxana B. Gluscencova, Erin S. Gloag, Tarek S. Awad, Jacquelyn D. Rich, Daniel Passos da Silva, Whitney Bond, François Le Mauff, Donald C. Sheppard, Benjamin D. Hatton, Paul Stoodley, Aaron W. Reinke, Gabrielle L. Boulianne, Daniel J. Wozniak, Joe J. Harrison, Matthew R. Parsek, P. Lynne Howell   +20 more
doaj   +1 more source

GH172 Difructose Dianhydride I Synthase: A Two‐Stepped Journey via Glycosylation and Cyclization Using QM/MM Metadynamics

Chemistry – A European Journal, EarlyView.
Unlocking the chemistry of caramel by simulations and experimental validation. αFFase1${\alpha }\rm{FFase1}$ converts inulobiose into difructose dianhydride I, one component of caramel, through two steps: a rate‐limiting glycosylation (with a rare sugar ring flip) followed by a cyclization step, guided by residues E85, K147, and N226.
Santiago Alonso‐Gil, Bruno Di Geronimo, Toma Kashima, Akihiro Ishiwata, Katsunori Tanaka, Kiyotaka Fujita, Shinya Fushinobu, Pedro A. Sánchez‐Murcia   +7 more
wiley   +1 more source

Glycoside hydrolase genes in genome sequences of B. longum.

, 2015
(A) Principal component analysis of the number of members of glycoside hydrolase families in genome sequences of B. longum. Subspecies longum, green circles; subspecies infantis, blue diamonds; subspecies.suis, red triangles.
Boris A. Efimov (783624), Alla P. Pikina (783627), Andrei N. Shkoporov (783628), Lyudmila I. Kafarskaia (783626), Andrei V. Chaplin (783623), Vladimir V. Smeianov (783625)   +5 more
core   +1 more source

Herb5GluCon: A novel polyherbal formulation with dual-action inhibiting properties against oxidative stress and glycoside hydrolases – an in silico and in vitro approach

Phytomedicine Plus
Introduction: Oxidative stress contributes to hyperglycaemia by inducing the hyperactivity of alpha-amylase (AA) and alpha-glucosidase (AG) enzymes. The study aimed to evaluate the antioxidant and anti-glycoside hydrolase potential of a novel polyherbal ...
Abbirami Balachandran, Patrick N. Okechukwu, Baskaran Gunasekaran, Jeleń Małgorzata, Beata Morak-Młodawska, Gabriele R.A. Froemming, Sameer Sapra, Charlie A. Lavilla, Jr., Merell P. Billacura, Salini D. Rajendran, Anis Najwa Abdul Rani, Anand Gaurav   +11 more
doaj   +1 more source

Ecophysiology of Freshwater Verrucomicrobia Inferred from Metagenome-Assembled Genomes

mSphere, 2017
Microbes are critical in carbon and nutrient cycling in freshwater ecosystems. Members of the Verrucomicrobia are ubiquitous in such systems, and yet their roles and ecophysiology are not well understood.
Shaomei He, Sarah L. R. Stevens, Leong-Keat Chan, Stefan Bertilsson, Tijana Glavina del Rio, Susannah G. Tringe, Rex R. Malmstrom, Katherine D. McMahon   +7 more
doaj   +1 more source

Enzymatic Synthesis of Novel Vitexin Glucosides

Molecules, 2021
Vitexin is a C-glucoside flavone that exhibits a wide range of pharmaceutical activities. However, the poor solubility of vitexin limits its applications. To resolve this limitation, two glycoside hydrolases (GHs) and four glycosyltransferases (GTs) were
Jiumn-Yih Wu, Tzi-Yuan Wang, Hsiou-Yu Ding, Yun-Rong Zhang, Shu-Yuan Lin, Te-Sheng Chang   +5 more
doaj   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source