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GLYCOSIDE HYDROLASES IN APLYSIA FASCIATA: ANALYSIS AND APPLICATIONS
Biotechnology and Genetic Engineering Reviews, 2008Glycosylation is considered to be an important reaction for the chemical modification of compounds with useful biological activities. Glycoside hydrolases are biotechnologically attractive enzymes which can be used in synthetic reactions for assembling glycosidic linkages with absolute stereoselectivity at an anomeric centre.
A Trincone +3 more
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Diversity of phosphorylases in glycoside hydrolase families
Applied Microbiology and Biotechnology, 2015Phosphorylases are useful catalysts for the practical preparation of various sugars. The number of known specificities was 13 in 2002 and is now 30. The drastic increase in available genome sequences has facilitated the discovery of novel activities.
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Structural and sequence-based classification of glycoside hydrolases
Current Opinion in Structural Biology, 1997The diversity of oligo- and polysaccharides provides an abundance of biological roles for these carbohydrates. The enzymes hydrolysing these compounds, the glycoside hydrolases, therefore mediate a wealth of biological functions. Glycoside hydrolases fall into a number of sequence-based families.
Henrissat, Bernard, Davies, G.
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Cln5 is secreted and functions as a glycoside hydrolase in Dictyostelium
Cellular Signalling, 2018Ceroid lipofuscinosis neuronal 5 (CLN5) is a member of a family of proteins that are linked to neuronal ceroid lipofuscinosis (NCL). This devastating neurological disorder, known commonly as Batten disease, affects all ages and ethnicities and is currently incurable. The precise function of CLN5, like many of the NCL proteins, remains to be elucidated.
Robert J. Huber +1 more
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Biocatalysis and Biotransformation, 2006
The glycoside hydrolases are a large group of enzymes that can be grouped into two major mechanistic classes based upon the stereochemical outcome of catalysis: retention and inversion of sugar anomeric configuration. Both mechanisms involve nucleophilic displacement at the anomeric center, and both proceed via positively charged oxocarbenium ion-like ...
Vivian L Y. Yip, Stephen G. Withers
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The glycoside hydrolases are a large group of enzymes that can be grouped into two major mechanistic classes based upon the stereochemical outcome of catalysis: retention and inversion of sugar anomeric configuration. Both mechanisms involve nucleophilic displacement at the anomeric center, and both proceed via positively charged oxocarbenium ion-like ...
Vivian L Y. Yip, Stephen G. Withers
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Modeling catalytic reaction mechanisms in glycoside hydrolases
Current Opinion in Chemical Biology, 2019Modeling catalysis in carbohydrate-active enzymes is a daunting challenge because of the high flexibility and diversity of both enzymes and carbohydrates. Glycoside hydrolases (GHs) are an illustrative example, where conformational changes and subtle interactions have been shown to be critical for catalysis.
Joan, Coines +2 more
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A GLYCOSIDE-HYDROLASE INHIBITOR IN TREATMENT OF DUMPING SYNDROME
The Lancet, 1979BAY g 5421, a glycoside-hydrolase inhibitor, produced symptomatic improvement in ten patients with the dumping syndrome. 100 mg BAY g 5421, given before a 50 g sucrose meal, produced pronounced attenuation of both hyperglycaemic and hypoglycaemic phases of plasma glucose levels; and it greatly reduced the rise in plasma levels of gastric inhibitory ...
J C, McLoughlin +2 more
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Purification of some glycoside hydrolases by affinity chromatography
Carbohydrate Research, 1977Two glycoproteins have been isolated from the cell walls of baker's yeast. One is a glucan-protein complex which has been partially characterised as having a branched carbohydrate structure composed of chains of (1 leads to 3)-linked beta-D-glucosyl residues, some of which are attached by (1 leads to 6)-linkages to the main chain.
M, Edward, R J, Sturgeon
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Phylogenetic analysis of family 6 glycoside hydrolases
Biopolymers, 2005AbstractMultiple sequence alignment separates members of glycoside hydrolase Family 6 into eight subfamilies: one of mainly actinobacterial endoglucanases (EGs), one of ascomycotal EGs, one of chytridiomycotal EGs and cellobiohydrolases (CBHs), one of actinobacterial and proteobacterial CBHs, one of chytridiomycotal CBHs, two of ascomycotal CBHs, and ...
Blake, Mertz +4 more
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Classification of glycoside hydrolases and glycosyltransferases from hyperthermophiles
2001Publisher Summary Glycoside hydrolases and glycosyltransferases are widespread groups of carbohydrate-active enzymes present in virtually all organisms and are involved, respectively, in the hydrolysis and in the biosynthesis of glycosidic bonds between carbohydrates or between a carbohydrate and a noncarbohydrate moiety.
B, Henrissat, P M, Coutinho
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