Results 101 to 110 of about 151,596 (239)

Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4

Phytotherapy Research, EarlyView.
Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou, Jingyun Chi, Yuan Ding, Zhidi Zhang, Rui Liang, Tianhao Wang, Yan Jiang, Rujun Song, Huazhou Fu, Xizhen Zhou   +9 more
wiley   +1 more source

A Review of Metal–Organic Framework (MOF) Based Active Food Packaging: Materials Selection, Cellulose Matrices Current Advances, Synthesis and Characterizations

Packaging Technology and Science, EarlyView.
Active packaging offers an effective approach to extending food shelf life. This review summarizes the past decade of progress in metal‐organic framework (MOF)‐based active food packaging, highlighting material selection, characterization, challenges, and future prospects.
Belladini Lovely, Young‐Teck Kim, Haibo Huang, Novitri Hastuti, Su Jung Hong   +4 more
wiley   +1 more source

A Chiral 2D Sheet for Enhancing GLUT1 Function Through the Interplay of Architecture and Recognition

Small, EarlyView.
We show that both supramolecular architecture and glucose chirality determine biological function. Unlike self‐assembled 0D particles, we assembled with OFN to form 2D sheets. Only the (d)‐sheets with exposed d‐glucose interacted with GLUT1, increasing its expression, promoting glucose uptake, and reducing ROS.
Yerim Kim, Dawoon Lee, Kyuri Kim, Young Yong Kim, Bongjun Yeom, Sunihl Ma, Young‐Hoon Kim, Yongju Kim   +7 more
wiley   +1 more source

A novel mechanistic insight: BYHWD glycosides promote vascular endothelial repair via EPCs. [PDF]

Eur J Med Res
Yan FC, Sun ZJ, Tan W, Ma L, Liu XD, Ding H, Zhang W.   +6 more
europepmc   +1 more source

Solamargine induces acute myeloid leukemia differentiation through TLR8 activation

VIEW, EarlyView.
SM, a steroidal alkaloid from Solanum nigrum L. has shown anticancer effect on various kinds of human cancer cells, yet its effect on leukemia cells remains unclear. This study examines antileukemic activities of SM in AML cells. Results indicate SM inhibits growth and promotes apoptosis of AML cells.
Qiaoyan Han, Yuting Chen, Zheyi Li, Yonglin Peng, Zhehan Hu, Yuliang Deng, Yanli Fu, Ming Cheng, Sheng Tan, Jing Tian, Xiaodong Zhao, Miao Sun   +11 more
wiley   +1 more source

Pd-catalyzed stereoretentive synthesis of reversed <i>C</i>-acyl glycosides: access to rare l-sugars and higher-carbon sugars. [PDF]

Chem Sci
Cheng G, Yang B, Zhu F.
europepmc   +1 more source

Integrating mass spectrometry and systems biology for the modernization of natural medicines: From deciphering chemical complexity to holistic efficacy assessment

VIEW, EarlyView.
This review explores how mass spectrometry is transforming research in natural medicines, with Traditional Chinese medicine (TCM) as a primary exemplar. It details the application of advanced mass spectrometry in chemical analysis, the development of comprehensive quality control methods, and systematic research on the targeted mechanisms of single ...
Yudian Xu, Linlin Cao, Chenhuan Ding, Chen Wang, Yi Lai, Dan Ru, He Li, Wei Xu   +7 more
wiley   +1 more source

Synthesis, Biological Evaluation, and Computational Studies of Phenolic <i>N</i>-Acetylglucosamine Glycosides as α-Glucosidase Inhibitors. [PDF]

Mar Drugs
Wang W, Gao K, Li G, Wang Z, Li K, Liu S, Yu H, Xing R.   +7 more
europepmc   +1 more source

Compact tape‐driven sample delivery system for serial femtosecond crystallography

Journal of Applied Crystallography, EarlyView.
A tape‐driven liquid sample droplet delivery system for serial femtosecond crystallography is described.We have developed a compact tape drive (CoT) with on‐demand sample delivery for time‐resolved serial femtosecond crystallography (SFX) experiments, which can deliver sample droplets and/or initiate reactions with a drop‐on‐drop strategy.
Jungmin Kang, Yoshiaki Shimazu, Fangjia Luo, Ayumi Yamashita, Tomoyuki Tanaka, Yuichi Inubushi, Kensuke Tono, Nipawan Nuemket, Allen M. Orville, So Iwata, Eriko Nango, Makina Yabashi   +11 more
wiley   +1 more source

Promiscuous Transferases Malonylate Furaneol Glucoside in <i>Fragaria</i> × <i>ananassa</i>. [PDF]

J Agric Food Chem
Wulanjati MP, Trinkl J, Wang X, Hoffmann T, Schwab W.   +4 more
europepmc   +1 more source