Results 61 to 70 of about 30,919 (277)

SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria

Biopharmaceutics & drug disposition, 2014
Sodium glucose cotransporter 2 (SGLT2) inhibitors have been reported to lower the serum uric acid (SUA) level. To elucidate the mechanism responsible for this reduction, SUA and the urinary excretion rate of uric acid (UEUA) were analysed after the oral ...
Y. Chino, Y. Samukawa, S. Sakai, Y. Nakai, J. Yamaguchi, T. Nakanishi, I. Tamai   +6 more
semanticscholar   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Early Diagnosis of Fanconi-Bickel Syndrome and a Novel Mutation inSLC2A2 Gene

Haseki Tıp Bülteni, 2019
Fanconi-Bickel syndrome is a metabolic disease caused by mutations in SCL2A2 gene. Hepatic and renal glycogen storage, fasting hypoglycemia, and renal tubular dysfunction are characteristics of the disease that is usually diagnosed at 6-10 months of age.
Ezgi Çelikboya, Mehmet Şerif Cansever, Tanyel Zübarioğlu, Gözde Yeşil, Nurver Akıncı   +4 more
doaj   +1 more source

Renal glucose handling in diabetes and sodium glucose cotransporter 2 inhibition

Indian Journal of Endocrinology and Metabolism, 2013
The kidneys play a major role in glucose homeostasis through its utilization, gluconeogenesis, and reabsorption via sodium glucose cotransporters (SGLTs).
Resham Raj Poudel
doaj   +1 more source

High urinary glucose is associated with improved renal prognosis in patients with diabetes mellitus

Journal of Diabetes Investigation, 2021
Aims/Introduction The relationship between renal function and urinary glucose is poorly understood in diabetes patients who are not using sodium–glucose cotransporter 2 inhibitors.
Yuya Itano, Hiroshi Sobajima, Norimi Ohashi, Taiga Shibata, Atsushi Fujiya, Takanobu Nagata, Masahiko Ando, Takahiro Imaizumi, Yoko Kubo, Takaya Ozeki, Takayuki Katsuno, Sawako Kato, Yoshinari Yasuda, Shoichi Maruyama   +13 more
doaj   +1 more source

Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria

Diabetes, 2015
Hypothalamic proopiomelanocortin (POMC) is essential for the physiological regulation of energy balance; however, its role in glucose homeostasis remains less clear. We show that hypothalamic arcuate nucleus (Arc)POMC-deficient mice, which develop severe
Kavaljit H. Chhabra, Jessica M. Adams, B. Fagel, D. Lam, Nathan R. Qi, M. Rubinstein, M. Low   +6 more
semanticscholar   +1 more source

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
wiley   +1 more source

Safe and pragmatic use of sodium–glucose co-transporter 2 inhibitors in type 2 diabetes mellitus: South Asian Federation of Endocrine Societies consensus statement

Indian Journal of Endocrinology and Metabolism, 2017
Diabetes prevalence shows a continuous increasing trend in South Asia. Although well-established treatment modalities exist for type 2 diabetes mellitus (T2DM) management, they are limited by their side effect profile.
Sanjay Kalra, Sujoy Ghosh, A H Aamir, Md. Tofail Ahmed, Mohammod Feroz Amin, Sarita Bajaj, Manash P Baruah, Uditha Bulugahapitiya, A K Das, Mimi Giri, Sonali Gunatilake, Saeed A Mahar, Md. Faruque Pathan, Nazmul Kabir Qureshi, S Abbas Raza, Rakesh Sahay, Santosh Shakya, Dina Shreshta, Noel Somasundaram, Manilka Sumanatilleke, A G Unnikrishnan, Achini Madushani Wijesinghe   +21 more
doaj   +1 more source

Insulin and glycosuria [PDF]

Diabetologia, 1971
An effect of insulin on glycosuria independent of its effect on blood sugar was demonstrated in a group of seven diabetics. To do this it was necessary to develop a technique in which the hypoglycaemic effect of insulin could be isolated and overcome.
openaire   +2 more sources

ALIMENTARY RENAL GLYCOSURIA

, 1918
Kingo Goto
openalex   +3 more sources