Comparative genomic analysis of the human gut microbiome reveals a broad distribution of metabolic pathways for the degradation of host-synthetized mucin glycans [PDF]
arXiv, 2017 The colonic mucus layer is a dynamic and complex structure formed by secreted and transmembrane mucins, which are high-molecular-weight and heavily glycosylated proteins. Colonic mucus consists of a loose outer layer and a dense epithelium-attached layer. The outer layer is inhabited by various representatives of the human gut microbiota (HGM). Glycans
arxiv
Mucin-inspired, high molecular weight virus binding inhibitors show biphasic binding behavior to influenza A viruses [PDF]
arXiv, 2020 Multivalent virus binding inhibitors are a promising new class of antivirals, preventing virus infection of cells by inhibiting the first step in the viral infection cycle - binding of viruses to the cell surface. The design of multivalent virus binding inhibitors is complex as many properties, such as inhibitor size and functionalization with virus ...
arxiv
Deconstruction of plant biomass by a Cellulomonas strain isolated from an ultra-basic (lignin-stripping) spring. [PDF]
, 2020 Plant material falling into the ultra-basic (pH 11.5-11.9) springs within The Cedars, an actively serpentinizing site in Sonoma County, California, is subject to conditions that mimic the industrial pretreatment of lignocellulosic biomass for biofuel ...
Bernie, Fujun +13 more
core
Oral Protein Therapy for the Future - Transport of Glycolipid-Modified Proteins: Vision or Fiction? [PDF]
, 2010 The reliable and early diagnosis of common complex multifactorial diseases depends on the individual determination of all (or as many as possible) polymorphisms of each susceptibility gene together with amount and type of the corresponding gene products ...
Mueller, Guenter
core +1 more source
ChemSusChem, Volume 18, Issue 8, April 14, 2025.New α‐glycosides of chalcones and dihydrochalcones, analogues of naturally occurring phlorizin, have been synthesized using a CGTase‐catalyzed glycosylation that was successfully scaled‐up in a 10‐liter reactor. The α‐glycosides were (i) purified using an original centrifugal partition chromatography technique, (ii) characterized through NMR and LC–MS ...
Laurène Minsat +12 more
wiley +1 more source
Glycosyl hydrolase from Pseudomonas fluorescens inhibits the biofilm formation of Pseudomonads
Biofilm, 2023 Biofilms are complex microbial communities embedded in extracellular matrix. Pathogens within the biofilm become more resistant to the antibiotics than planktonic counterparts. Novel strategies are required to encounter biofilms.
Di Wang +5 more
doaj
Efficient and minimal length parametric conformal prediction regions [PDF]
arXiv, 2019 Conformal prediction methods construct prediction regions for iid data that are valid in finite samples. We provide two parametric conformal prediction regions that are applicable for a wide class of continuous statistical models. This class of statistical models includes generalized linear models (GLMs) with continuous outcomes.
arxiv
Automated glycan assembly of arabinomannan oligosaccharides from Mycobacterium tuberculosis [PDF]
, 2019 Arabinomannan (AM) polysaccharides are clinical biomarkers for Mycobacterium tuberculosis (MTB) infections due to their roles in the interaction with host cells and interference with macrophage activation.
Bharate, Priya +3 more
core +1 more source
ChemSusChem, EarlyView.This study presents a whole valorization of apple processing waste: phloretin is efficiently produced from phloridzin (abundantly found in apple residues), using a β‐glycosidase immobilized on bacterial cellulose in a biphasic system. Notably, bacterial cellulose is derived from fermentation of apple pomace sugars, making both the enzyme carrier and ...
Agostina Colacicco +6 more
wiley +1 more source
Cloning of a Carcinoembryonic Antigen Gene Family Member Expressed in Leukocytes of Chronic Myeloid Leukemia Patients and Bone Marrow [PDF]
, 1990 The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin superfamily and can be subdivided into the CEA and pregnancy-specific glycoprotein subgroups.
Berling, Barbara +7 more
core +1 more source