Results 161 to 170 of about 81,861 (342)

Spatio‐temporal characteristics of the gastrointestinal resistome in a cow‐to‐calf model and its environmental dissemination in a dairy production system

open access: yesiMeta, EarlyView.
This study revealed spatio‐temporal characteristics of gastrointestinal resistome in a cow‐to‐calf model and the pattern of their spread to the environment and offspring in the dairy production system. The gastrointestinal tract of dairy cows is a natural reservoir of resistomes and distinguished by gut sites and regions.
Shuai Liu   +19 more
wiley   +1 more source

Predicting O-GlcNAcylation Sites in Mammalian Proteins with Transformers and RNNs Trained with a New Loss Function [PDF]

open access: yesarXiv
Glycosylation, a protein modification, has multiple essential functional and structural roles. O-GlcNAcylation, a subtype of glycosylation, has the potential to be an important target for therapeutics, but methods to reliably predict O-GlcNAcylation sites had not been available until 2023; a 2021 review correctly noted that published models were ...
arxiv  

Research progress of antibody coupling technique in targeted drug delivery

open access: yesInterdisciplinary Medicine, EarlyView.
Abstract Antibody‐drug conjugates are a cutting‐edge biotechnology recently attracting wide attention in the medical field. Binding antibodies to drug molecules could deliver drugs precisely to the site of the lesion, which shows great potential in the treatment of tumors and immune diseases.
Meng Li   +6 more
wiley   +1 more source

Quantitative determination of the neutral glycosyl ceramides in human blood

open access: yesJournal of Lipid Research, 1967
A method is described for the qualitative and quantitative estimation of four neutral glycosyl ceramides from human plasma and erythrocytes. Total lipids extracted from 50 ml of plasma or packed erythrocytes were separated by silicic acid chromatography ...
Dennis E. Vance, Charles C. Sweeley
doaj  

Sulfated Glycosaminoglycans as Inhibitors for Chlamydia Infections: Molecular Weight and Sulfation Dependence

open access: yesMacromolecular Bioscience, Volume 25, Issue 4, April 2025.
Interactions between sulfated glycosaminoglycans (GAGs) and the adhesin OmcB of Chlamydia species are explored using a surface‐based binding assay and cell assays. Increased sulfation and molecular weight enhance GAG binding and reduce bacterial attachment, with heparin exhibiting superior inhibitory effects.
Sebastian Wintgens   +7 more
wiley   +1 more source

Exploring the dynamic landscape of immunopeptidomics: Unravelling posttranslational modifications and navigating bioinformatics terrain

open access: yesMass Spectrometry Reviews, EarlyView.
Abstract Immunopeptidomics is becoming an increasingly important field of study. The capability to identify immunopeptides with pivotal roles in the human immune system is essential to shift the current curative medicine towards personalized medicine. Throughout the years, the field has matured, giving insight into the current pitfalls. Nowadays, it is
Daniel Flender   +5 more
wiley   +1 more source

Effects of Natural Polysaccharides on the Gut Microbiota Related to Human Metabolic Health

open access: yesMolecular Nutrition &Food Research, EarlyView.
The graphical abstract illustrates the role of polysaccharides extracted from various natural raw materials (such as mushrooms, marine organisms, fruits, and vegetables) in modulating the gut microbiota. The process begins with the extraction and purification of polysaccharides, followed by assessing their structure‐activity relationship. Upon entering
Yigang Huang   +7 more
wiley   +1 more source

Isolation and Characterization of Poly(glycosyl)ceramides (Megaloglycolipids) with A, H and I Blood‐Group Activities [PDF]

open access: bronze, 1976
Jerzy Kościelak   +3 more
openalex   +1 more source

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