Results 11 to 20 of about 54,595 (236)

Efficient Preparation of Homogenous Antibody Conjugates via Glycosite‐Specific Transglycosylation Enabled by Readily Available Glycosyl Donors

Angewandte Chemie, EarlyView.
A streamlined platform for glycosite‐specific antibody conjugation is enabled by LacNAc‐derived cyclic acetal donors, which can be prepared in only two steps and used directly in single‐enzyme Endo S2‐mediated transglycosylation. The platform supports the broad construction of homogeneous gsADCs and gsDACs, with donor 7 producing glycoengineered ...
Deqin Cai, Yuan Zhao, Gaoyuan Lu, C Li, Yichong Lao, Ramesh Mudududdla, Jiahao Zhang, Peijing Jia, Penghsuan Huang, Wenxin Wu, Thao‐Vy T. Nguyen, Xuhui Huang, Lingjun Li, Weiping Tang   +13 more
wiley   +3 more sources

Phenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cells

Haematologica, 2010
Background Somatic mutation in the X-linked phosphatidylinositol glycan class A gene (PIG-A) causes glycosyl phosphatidylinositol anchor deficiency in human patients with paroxysmal nocturnal hemoglobinuria.Design and Methods We produced an animal model ...
Valeria Visconte, Nalini Raghavachari, Delong Liu, Keyvan Keyvanfar, Marie J. Desierto, Jichun Chen, Neal S. Young   +6 more
doaj   +1 more source

Identification of C-glycosyl flavones by high performance liquid chromatography electrospray ionization mass spectrometry and quantification of five main C-glycosyl flavones in Flickingeria fimbriata

BMC Chemistry, 2019
Flickingeria fimbriata is commonly applied in China as a traditional Chinese medicine (TCM), however the quality control of it is incomplete. In this work, we aim to identify and quantify the structures of C-glycosyl flavones in F. fimbriata.
Yawen Wang, Zhiyun Liang, Xian Liao, Chujuan Zhou, Zhenshan Xie, Sha Zhu, Gang Wei, Yuechun Huang   +7 more
doaj   +1 more source

A Concise Synthesis of a BODIPY-Labeled Tetrasaccharide Related to the Antitumor PI-88

Molecules, 2021
A convergent synthetic route to a tetrasaccharide related to PI-88, which allows the incorporation of a fluorescent BODIPY-label at the reducing-end, has been developed.
Juan Ventura, Clara Uriel, Ana M. Gomez, Edurne Avellanal-Zaballa, Jorge Bañuelos, Inmaculada García-Moreno, Jose Cristobal Lopez   +6 more
doaj   +1 more source

C-Glycosylated flavonoids from black gram husk: Protection against DNA and erythrocytes from oxidative damage and their cytotoxic effect on HeLa cells

Toxicology Reports, 2016
C-Glycosyl flavones are present in different plant tissues and they exhibit health benefits. In the present study, it was found that C-glycosyl flavones are distributed in different milled fractions of black gram and among these fractions, husk had the ...
T.K. Girish, K. Anil Kumar, U.J.S. Prasada Rao   +2 more
doaj   +1 more source

Appel-reagent-mediated transformation of glycosyl hemiacetal derivatives into thioglycosides and glycosyl thiols

Beilstein Journal of Organic Chemistry, 2013
A series of glycosyl hemiacetal derivatives have been transformed into thioglycosides and glycosyl thiols in a one-pot two-step reaction sequence mediated by Appel reagent (carbon tetrabromide and triphenylphosphine).
Tamashree Ghosh, Abhishek Santra, Anup Kumar Misra   +2 more
doaj   +1 more source

Golgi Glycosylation [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Glycosylation is a very common modification of protein and lipid, and most glycosylation reactions occur in the Golgi. Although the transfer of initial sugar(s) to glycoproteins or glycolipids occurs in the ER or on the ER membrane, the subsequent addition of the many different sugars that make up a mature glycan is accomplished in the Golgi.
openaire   +2 more sources

Enhanced Selectivity of Chalcogen Bonding over Halogen Bonding Catalyzed C-glycosylation Through Differentiated Intermediate Activation. [PDF]

Angew Chem Int Ed Engl
By harnessing chalcogen bonding (ChB) catalysis, an exclusive access into a highly stereoselective strain‐release C‐glycosylation pathway was discovered. This was surprisingly not replicable by the conceptually similar halogen bonding (XB) catalysis.
Guo H, Loh CCJ.
europepmc   +3 more sources

A new synthetic access to 2-N-(glycosyl)thiosemicarbazides from 3-N-(glycosyl)oxadiazolinethiones and the regioselectivity of the glycosylation of their oxadiazolinethione precursors

Beilstein Journal of Organic Chemistry, 2013
Glycosylations of 5-(1H-indol-2-yl)-1,3,4-oxadiazoline-2(3H)-thione delivered various degrees of S- and/or N-glycosides depending on the reaction conditions.
El Sayed H. El Ashry, El Sayed H. El Tamany, Mohy El Din Abdel Fattah, Mohamed R. E. Aly, Ahmed T. A. Boraei, Axel Duerkop   +5 more
doaj   +1 more source

Chemistry of 1,2-Anhydro Sugars

CHIMIA, 2018
The 1,2-anhydro sugars are a class of valuable and versatile intermediates in carbohydrate chemistry. In the first part of this article, a review is given on preparation methods of 1,2-anhydro sugars that are suitably protected.
Gefei Li, Masato Noguchi, Kazunari Serizawa, Shin-Ichiro Shoda   +3 more
doaj   +1 more source