Results 31 to 40 of about 54,595 (236)
Current Biology, 2019 Eichler introduces the diversity of protein glycosylations and the roles of these modifications in regulating protein function.
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Advanced Science, EarlyView.A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li +7 more
wiley +1 more source
GASdb: a large-scale and comparative exploration database of glycosyl hydrolysis systems
BMC Microbiology, 2010 Background The genomes of numerous cellulolytic organisms have been recently sequenced or in the pipeline of being sequenced. Analyses of these genomes as well as the recently sequenced metagenomes in a systematic manner could possibly lead to ...
Xu Ying, Chen Huiling, Zhou Fengfeng
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Nature Communications, 2023 Catalytic glycosylation is a vital transformation in synthetic carbohydrate chemistry due to its ability to expediate the large-scale oligosaccharide synthesis for glycobiology studies with the consumption of minimal amounts of promoters.
Han Ding +4 more
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Glycosyl hydrolase from Pseudomonas fluorescens inhibits the biofilm formation of Pseudomonads
Biofilm, 2023 Biofilms are complex microbial communities embedded in extracellular matrix. Pathogens within the biofilm become more resistant to the antibiotics than planktonic counterparts. Novel strategies are required to encounter biofilms.
Di Wang +5 more
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Stereoselective Ferrier‐Type O‐Glycosylation Enabled by Difluoromethylated Glycal Donors
Advanced Science, EarlyView.A fluorine‐mediated stereoselective Ferrier‐type glycosylation is reported. Glycals are pre‐decorated with photo‐2‐difluoroalkylation and reacted with diverse acceptors to obtain exclusively α‐selective Ferrier rearrangement products. Abstract The effective construction of structurally homogeneous glycosides is requisite in oligosaccharide assembly and
You Zou +5 more
wiley +1 more source
Novel glycosyl prodrug of RXP03 as MMP-11 prodrug: design, synthesis and virtual screening
BMC Chemistry, 2023 Like most phosphinic acids, the potent and selective RXP03 inhibitor of different MMPs exhibited moderate absorption and low bioavailability, which impaired its use. In an unprecedented attempt, we present an interesting synthetic approach to a new class
Moaz M. Abdou +3 more
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Functional Characterization of a Flavone Synthase That Participates in a Kumquat Flavone Metabolon
Frontiers in Plant Science, 2022 Flavones predominantly accumulate as O- and C-glycosides in kumquat plants. Two catalytic mechanisms of flavone synthase II (FNSII) support the biosynthesis of glycosyl flavones, one involving flavanone 2-hydroxylase (which generates 2-hydroxyflavanones ...
Shulin Tian +14 more
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Stereoselective glycosylations using oxathiane spiroketal glycosyl donors [PDF]
Carbohydrate Research, 2012 Novel oxathiane spiroketal donors have been synthesised and activated via an umpolung S-arylation strategy using 1,3,5-trimethoxybenzene and 1,3-dimethoxybenzene. The comparative reactivity of the resulting 2,4,6-trimethoxyphenyl (TMP)- and 2,4-dimethoxyphenyl (DMP)-oxathiane spiroketal sulfonium ions is discussed, and their α-stereoselectivity in ...
Fascione, MA +4 more
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