Results 161 to 170 of about 232,627 (303)

A rhesus macaque model of α‐dystroglycanopathy caused by a POMT1 splice altering variant

Animal Models and Experimental Medicine, EarlyView.
Rhesus macaques homozygous for a naturally occurring spice altering variant in the POMT1 gene develop lissencephaly, microphthalmia, and muscular contracture. The presentation models severe presentation of the human Walker‐Warburg syndrome. Abstract Background Biallelic mutations in genes associated with α‐dystroglycan glycosylation manifest in a ...
Anya Nordlund, Brian LaMendola, Nathan P. Crilly, Seth Kittle, Betsy M. Ferguson, Anne D. Lewis, Jeff Wall, Samuel M. Peterson   +7 more
wiley   +1 more source

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, EarlyView.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

A Portal‐Preorganized Cucurbit[7]uril‐Ruthenium Conjugate Enables Motif‐Selective Protein Sensing

Angewandte Chemie International Edition, EarlyView.
Reprogramming cucurbit[7]uril (CB7) recognition through portal engineering transforms an optically silent host into a motif‐selective photoluminescent receptor. The portal‐preorganized CB7‐Rubpy conjugate directly reports changes in aromatic motif accessibility, enabling optical sensing of protein misfolding and refolding.
Patrick Gruhs, Albert Kraft, Vahideh Mahram, Marco Neumaier, Papri Chakraborty, Emily Janz, Maria Vittoria Balli, Pierre Picchetti, Luca Prodi, Manfred Kappes, Frank Biedermann   +10 more
wiley   +1 more source

IgG Glycosylation Patterns May Identify Distinct Clinical Trajectories in Fibromyalgia Patients: A Longitudinal Pilot Study. [PDF]

Eur J Pain
Kung LC, Nhu NT, Yu YY, Tsai IL, Kang JH.   +4 more
europepmc   +1 more source

From glycosylation to deglycosylation: Unraveling the complete deglycosylation processing pathway of <i>Drosophila</i> rhodopsin. [PDF]

Sci Prog
Chen X, Yuan Y, Zhong Y, Huang Y, Ouyang S, Xue Q, Qin Y, Hu X, Huang Y, Cao J.   +9 more
europepmc   +1 more source

Altered glycosylation of proteins in cancer: what is the potential for new anti-tumour strategies

, 2008
It is becoming increasingly apparent that cell surface oligosaccharides play pivotal roles as recognition molecules in a range of cell communication and adhesion processes.
Carter, T.M., Royle, L., Brooks, S.A., Fry, S., Kinch, C., Dwek, R.A., Rudd, P.M., Harvey, D.J.   +7 more
core  

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Protein Glycosylation and Its Role in Current Immunotherapeutic Strategies. [PDF]

Cancers (Basel)
Agostini M, Traldi P, Hamdan M.
europepmc   +1 more source

Integrating GlycoSHIELD Modeling and DNA-PAINT SMLM to Map the Glycosylation-Dependent Distribution of the Na,K-ATPase. [PDF]

J Membr Biol
Stojcic B, Draczkowski P, Patrick J, Saeed M, Brismar H.   +4 more
europepmc   +1 more source

Site-Specific Glycosylation Profiling of Protein Subunit and Inactivated Virus Vaccines. [PDF]

Vaccines (Basel)
Goecker ZC, Burke MC, Liu Y, Mirokhin YA, Sheetlin SL, Wang G, Tchekhovskoi DV, Yang X, Stein SE.   +8 more
europepmc   +1 more source