Results 71 to 80 of about 255,241 (301)

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

Science Advances, 2020
Variation in key transcription factors and glycogenes modifies IgG glycosylation and has an influence on inflammatory diseases. Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan moiety, thus affecting activity of ...
L. Klarić, Y. Tsepilov, Chloe M. Stanton, M. Mangino, Timo Tõnis Sikka, T. Esko, E. Pakhomov, P. Salo, J. Deelen, S. McGurnaghan, Toma Keser, F. Vučković, I. Ugrina, J. Krištić, I. Gudelj, J. Štambuk, R. Plomp, M. Pučić-Baković, Tamara Pavić, Marija Vilaj, I. Trbojević-Akmačić, Camilla Drake, P. Dobrinić, J. Mlinarec, B. Jelušić, Anne Richmond, M. Timofeeva, A. Grishchenko, Julia Dmitrieva, M. Bermingham, S. Sharapov, S. Farrington, E. Theodoratou, H. Uh, M. Beekman, E. Slagboom, E. Louis, M. Georges, M. Wuhrer, H. Colhoun, M. Dunlop, M. Perola, K. Fischer, O. Polašek, H. Campbell, I. Rudan, James F. Wilson, V. Zoldoš, V. Vitart, T. Spector, Y. Aulchenko, G. Lauc, C. Hayward   +52 more
semanticscholar   +1 more source

Thermally Modulated Metasurface Sensor for Dynamic and Time‐Resolved Isolation of Extracellular Vesicles

Advanced Materials, EarlyView.
A thermally adaptive plasmonic metasurface, functionalized with poly(N‐isopropylacrylamide) (PNIPAM) and anti‐CD63 antibodies, enables precise, on‐demand capture and release of extracellular vesicles (EVs). Delivering high recovery, improved purity, and intact vesicle structure, the platform offers a versatile, label‐free solution for real‐time EV ...
Beyza Nur Kucuk, Eylul Gulsen Yilmaz, Yusuf Aslan, Emre Ece, Özgecan Erdem, Murat Alp Gungen, Bengi Özgün Öztürk, Fatih Inci   +7 more
wiley   +1 more source

Aberrant glycosylation in schizophrenia: insights into pathophysiological mechanisms and therapeutic potentials

Frontiers in Pharmacology
Schizophrenia (SCZ) is a severe neuropsychiatric disorder characterized by cognitive, affective, and social dysfunction, resulting in hallucinations, delusions, emotional blunting, and disordered thinking.
Yanchen Feng, Yanchen Feng, Lu Sun, Xue Dang, Diyan Liu, Ziyun Liao, Jianping Yao, Yunke Zhang, Ziqi Deng, Jinyao Li, Min Zhao, Min Zhao, Feixiang Liu, Feixiang Liu   +13 more
doaj   +1 more source

Understanding the role of antibody glycosylation through the lens of severe viral and bacterial diseases

Glycobiology, 2020
Abundant evidence points to a critical role for antibodies in protection and pathology across infectious diseases. While the antibody variable domain facilitates antibody binding and the blockade of infection, the constant domain (Fc) mediates cross talk
Edward B. Irvine, G. Alter
semanticscholar   +1 more source

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Model-based analysis of N-glycosylation in Chinese hamster ovary cells. [PDF]

PLoS ONE, 2017
The Chinese hamster ovary (CHO) cell is the gold standard for manufacturing of glycosylated recombinant proteins for production of biotherapeutics. The similarity of its glycosylation patterns to the human versions enable the products of this cell line ...
Frederick J Krambeck, Sandra V Bennun, Mikael R Andersen, Michael J Betenbaugh   +3 more
doaj   +1 more source

Immunoglobulin G glycosylation in aging and diseases.

Cellular Immunology, 2018
The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows a significant degree of variation within populations. IgG glycome composition is influenced both by genes and by environment, making it an excellent biomarker of a person's ...
I. Gudelj, G. Lauc, M. Pezer
semanticscholar   +1 more source

Integrative glycoproteomics reveals protein N-glycosylation aberrations and glycoproteomic network alterations in Alzheimer’s disease

Science Advances, 2020
Disease-associated glycoproteome changes identified in human brain provide new insights into Alzheimer’s disease pathogenesis. Protein N-glycosylation plays critical roles in controlling brain function, but little is known about human brain N ...
Qi Zhang, Cheng Ma, L. Chin, Lian Li
semanticscholar   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source