Results 71 to 80 of about 602 (161)

Chemical Rescue Serves as a Predictive Proxy for Glycosynthase Activity on Glycosidic Bonds via a Shared Glycosyl Oxocarbenium Transition State

Engineered glycosynthases (GSs) are powerful biocatalysts for custom glycan synthesis, yet their optimization via directed evolution is severely constrained by bottlenecks in high-throughput screening for activated azido-sugar donors.
Chandra Kanth Bandi, T. Emme Burgin, Sri Vidya Vyjayanthi Tallavajhula, Mohit Kumar, Srinivas V. S. Chakravartula, Shishir P. S. Chundawat   +5 more
core   +1 more source

Evaluation of Two Chemoenzymatic Glycan Remodeling Approaches to Generate Site-Specific Antibody-Drug Conjugates. [PDF]

Antibodies (Basel), 2023
Yang Q, Chen H, Ou C, Zheng Z, Zhang X, Liu Y, Zong G, Wang LX.   +7 more
europepmc   +1 more source

Preparation of a glycosynthase from the beta-glycosidase of the hyperthermophilic Archaeon Pyrococcus horikoshii.

, 2006
The b -glycosidase from the hyperthermophilic Archaeon Pyrococcus horikoshii (Phob-gly) is a monomeric enzyme with wide substrate specificity belonging to family 1 of glycoside hydrolases classification.
G. PERUGINO, MORACCI, Marco, I. MATSUI, CORSARO, MARIA MICHELA, PARRILLI, MICHELANGELO, P. FALCICCHIO, ROSSI, MOSE'   +6 more
core  

Computer Simulation to Rationalize "Rational" Engineering of Glycoside Hydrolases and Glycosyltransferases. [PDF]

J Phys Chem B, 2022
Coines J, Cuxart I, Teze D, Rovira C.
europepmc   +1 more source

Hydrolase and glycosynthase activity by endo-1,3-B-glucanase from the thermophile Pyrococcus furiosus

, 2004
Pyrococcus furiosus laminarinase (LamA, PF0076) is an endo-glycosidase that hydrolyzes beta-1,3-glucooligosaccharides, but not beta-1,4-gluco-oligosaccharides.
Nieto, J., Oost, J., van der, Lieshout, J.F.T., van, Faijes, M., Planas, A.   +4 more
core  

Modulating antibody effector functions by Fc glycoengineering. [PDF]

Biotechnol Adv, 2023
García-Alija M, van Moer B, Sastre DE, Azzam T, Du JJ, Trastoy B, Callewaert N, Sundberg EJ, Guerin ME.   +8 more
europepmc   +1 more source

Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments. [PDF]

Microb Cell Fact, 2022
Zhang M, Kong L, Gong R, Iorio M, Donadio S, Deng Z, Sosio M, Chen W.   +7 more
europepmc   +1 more source

Catalytic Efficiency for the Chemoenzymatic Synthesis of Core Human Milk Oligosaccharides and Analogs via Sugar Oxazolines. [PDF]

J Agric Food Chem
Penhallurick RW, Meares A, Ellis GA, Hooe SL, Breger JC, Medintz IL.   +5 more
europepmc   +1 more source

Conversion of an Inverting Glycoside Hydrolase into Glycosynthase

Journal of Applied Glycoscience, 2009
Honda, Yuji, Fushinobu, Shinya, Hidaka, Masafumi, Wakagi, Takayoshi, Shoun, Hirofumi, Taniguchi, Hajime, Kitaoka, Motomitsu   +6 more
openaire   +2 more sources

Synthesis of cellulosic glycolipids using engineered enzymes

, 2014
Cellulose, a linear polymer of D-glucose units connected by β-1,4 glycosidic bonds, adopts a highly-ordered crystalline structure in solution. In cellulose I, the dominant form of cellulose in nature, the polymeric chains are aligned in the same ...
Chambers, Martina Natasha
core