Results 51 to 60 of about 602 (161)
, 2016 Control of the monomer sequence in polymers is extraordinarily difficult by chemical synthesis, though Nature routinely exerts such control, including in the biosynthesis of polysaccharides.
Kevin J. Edgar (2554861) +3 more
core +1 more source
Glycosynthases: New Tools for Oligosaccharide Synthesis.
Trends in Glycoscience and Glycotechnology, 2002 生命現象におけるオリゴ糖鎖の多様な働きが次々と明らかにされている。オリゴ糖の持つ生理活性をより深く理解し利用していくためには、天然型および非天然型オリゴ糖を入手する必要がある。したがって、オリゴ糖合成は化学における最も活発に研究されている分野の一つとなっている。ここで紹介するグリコシンターゼは全く新しいタイプの変異酵素であり、有機化学的な方法や糖転移酵素を用いる従来法と共に、オリゴ糖合成に利用することができる。グリコシンターゼとは、糖加水分解酵素の触媒部位の求核性アミノ酸を非求核性アミノ酸で置換した変異体のことであり、加水分解に対して不活性である。しかし、糖受容体の存在下、糖-酵素中間体に類似した構造をもつ糖供与体に作用させると、高収率で糖転移反応を進行させることができる。本総説は ...
Jakeman, David L., Withers, Stephen G.
openaire +2 more sources
Glycosynthase Technology for Enzymatic Synthesis of Functionalized Artificial Polysaccharides as New Biomaterials [PDF]
, 2015 La tecnologia glicosintasa ha esdevingut una eina important per a la síntesi d’oligosacàrids, polisacàrids i glicoconjugats. Les glicosintases són glicosidases mutades desproveïdes d’activitat hidrolítica però capaces de catalitzar eficientment la ...
Codera Pastor, Maria Victoria
core
Preparation of a glycosynthase from the beta-glycosidase of the Archaeon Pyrococcus horikoshii
, 2006 The beta-glycosidase from the hyperthermophilic Archaeon Pyrococcus horikoshii (Phobeta-gly) is a monomeric enzyme with wide substrate specificity belonging to family 1 of glycoside hydrolases classification. Inspection of the three-dimensional structure
Moracci M +6 more
core +1 more source
, 2015 Glycosynthases are becoming important enzymatic tools for the synthesis of oligosaccharides. Herein, we explore for the first time the synthesis of a-glycoconjugates using a a-glycosynthase in green solvents.
Bayón, C. +6 more
core +1 more source
Glycosynthases - Tuning glycosidase activity towards glycoside diversification and synthesis
, 2019 With the aim of producing and applying new glycosynthases towards the synthesis of glycosides, the results obtained during the work of this thesis highlighted various aspects not only of the glycosynthase-catalysed reaction but also of the process of ...
Hayes, Marc Richard, Hayes, Marc
core
Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
, 2008 The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields.
Mohd. Salleh, Hamzah +5 more
core +1 more source
Flavonoids as Aglycones in Retaining Glycosidase-Catalyzed Reactions: Prospects for Green Chemistry. [PDF]
J Agric Food Chem, 2023 Kotik M, Kulik N, Valentová K.
europepmc +1 more source
, 2003 Complex oligosaccharides with newly formed (1,3)-β-glycosidic linkages were obtained in good to excellent yields when substituted or unsubstituted α-laminaribiosyl fluorides, acting as donors, were condensed onto mono- and disaccharide β-D-hexopyranoside
Hrmova, M. +4 more
core +1 more source
Innovative Preparation of Biopharmaceuticals Using Transglycosylation Activity of Microbial Endoglycosidases. [PDF]
J Appl Glycosci (1999), 2021 Katoh T, Yamamoto K.
europepmc +1 more source