Results 141 to 150 of about 5,898,960 (197)
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Glycyrrhetinic acid-cyclodextrin grafted pullulan nanoparticles loaded doxorubicin as a liver targeted delivery carrier.

International Journal of Biological Macromolecules, 2022
In this work, glycyrrhetinic acid (GA)-β-cyclodextrin grafted pullulan (GCDPu) was synthesized and used to form nanoparticles for liver-specific drug delivery.
Wenzhi Yang   +4 more
semanticscholar   +1 more source

Self-assembled glycyrrhetinic acid derivatives for functional applications: a review.

Food & Function, 2022
Glycyrrhetinic acid (GA), a famous natural product, has been attracting more attention recently because of its remarkable biological activity, natural sweetness, and good biocompatibility.
Lin Zou   +7 more
semanticscholar   +1 more source

18β-Glycyrrhetinic acid protects against deoxynivalenol-induced liver injury via modulating ferritinophagy and mitochondrial quality control.

Journal of Hazardous Materials
Deoxynivalenol (DON), a widespread mycotoxin, represents a substantial public health hazard due to its propensity to contaminate agricultural produce, leading to both acute and chronic health issues in humans and animals upon consumption.
Junze Jiang   +6 more
semanticscholar   +1 more source

A Mini-Review on Structure-Activity Relationships of Glycyrrhetinic Acid Derivatives with Diverse Bioactivities.

Mini-Reviews in Medical Chemistry, 2022
Pentacyclic triterpenoids, consisting of six isoprene units, are a kind of natural active substance. At present, numerous pentacyclic triterpene have been observed and classified into four subgroups of oleanane, ursane, lupane, and xylene on the basis of
Yuebin Liu   +3 more
semanticscholar   +1 more source

TPGS assists the percutaneous administration of curcumin and glycyrrhetinic acid coloaded functionalized ethosomes for the synergistic treatment of psoriasis.

International journal of pharmaceutics, 2021
Combined therapy with anti-inflammatory drugs is preferred for the topical treatment of psoriasis, but the codelivery of drugs is restricted due to the lack of a suitable delivery system.
Teng Guo   +6 more
semanticscholar   +1 more source

New 18β‐Glycyrrhetinic Acid‐Emodin Esters Synthetized by a One‐Step Innovative Route, Its Structural Characterization, and in Vivo Toxicity Assessed on Zebrafish Models

Chemistry and Biodiversity, 2022
To integrate the active advantages of 18β‐glycyrrhetinic acid (18β‐GA) and emodin, improve bioavailability, increase efficiency, and reduce toxicity, a one‐step innovative synthetic route was set up for the first time: 4‐dimethylaminopyridine (DMAP) was ...
Y. Zhong   +4 more
semanticscholar   +1 more source

Glycyrrhetinic acid proliposomes mediated by mannosylated ligand: Preparation, physicochemical characterization, environmental stability and bioactivity evaluation.

Colloids and Surfaces B: Biointerfaces, 2022
Glycyrrhetinic acid is a bioactive compound extracted from licorice that exhibits inhibition effect on various cancers. However, its hydrophobicity results in low bioavailability that limits application.
J. Chen   +9 more
semanticscholar   +1 more source

Antileukæmic Activity of Glycyrrhetinic Acid

Nature, 1960
RECENTLY some pharmacologically interesting activities of glycyrrhetinic acid corresponding to those observed with the adrenal cortical hormones have been shown; for example, a DOCA-like effect on sodium and potassium metabolism in normal people1 and an anti-inflammatory activity in different animal tests2.
W, LOGEMANN   +3 more
openaire   +2 more sources

18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2.

Food & Function, 2021
Osteoarthritis (OA) is presently the most prevalent form of chronic degenerative joint disease, which is characterized by erosion of articular cartilage, subchondral bone sclerosis and synovitis. Accumulating evidence has revealed that 18β-glycyrrhetinic
Boda Chen   +11 more
semanticscholar   +1 more source

Glycyrrhetinic acid derivatives as Zika virus inhibitors: Synthesis and antiviral activity in vitro.

Bioorganic & Medicinal Chemistry, 2021
Zika virus (ZIKV) is an arbovirus of the Flaviviridae family (Flavivirus genus), causing serious neurological complications, such as Guillain-Barre Syndrome (GBS) in adults and fetal microcephaly.
L. Baltina   +11 more
semanticscholar   +1 more source

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