Results 161 to 170 of about 11,518 (273)

Circadian Rhythm: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 11, November 2025.
This review offers a comprehensive overview of the mechanisms by which circadian rhythms modulate tissue homeostasis, alongside the associations between circadian disturbances and circadian rhythm‐related diseases. Furthermore, we offer insights into circadian rhythm‐regulating therapies, which may contribute to the development of novel strategies for ...
Kangkang Zha, Bobin Mi, Yuan Xiong, Shuyan Wu, Li Lu, Shengming Zhang, Xuan Lu, Hei Chung Mak, Jianping Huang, Adriana C. Panayi, Samuel Knoedler, Lili Chen, Guohui Liu, Sien Lin   +13 more
wiley   +1 more source

Development of an echo‐shifted, multi‐echo, gradient‐echo sequence for T2* quantification of slow‐relaxing water pools

Magnetic Resonance in Medicine, Volume 94, Issue 5, Page 2057-2070, November 2025.
Abstract Purpose Although conventional multi‐echo gradient‐echo (GRE) sequences effectively quantify short and intermediate T2* in brain tissue, and general interest in cerebrospinal fluid (CSF) is growing due to its association with the glymphatic system, quantifying T2* in CSF remains underexplored.
Seonyeong Shin, Ana‐Maria Oros‐Peusquens, Seong Dae Yun, Ezequiel Farrher, N. Jon Shah   +4 more
wiley   +1 more source

Genetically Engineered T-Cells for Malignant Glioma: Overcoming the Barriers to Effective Immunotherapy. [PDF]

, 2018
Malignant gliomas carry a dismal prognosis. Conventional treatment using chemo- and radiotherapy has limited efficacy with adverse events. Therapy with genetically engineered T-cells, such as chimeric antigen receptor (CAR) T-cells, may represent a ...
Almeida, Neil D, Chuntova, Pavlina, Downey, Kira M, Hegde, Bindu, Okada, Hideho   +4 more
core  

The Glymphatic System: A Review of the Challenges in Visualizing its Structure and Function with MR Imaging

, 2020
Shinji Naganawa, Toshiaki Taoka
openalex   +2 more sources

Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power

Acta Ophthalmologica, Volume 103, Issue 7, Page e511-e523, November 2025.
Abstract Purpose The study aims to investigate the effect of pharmacologically reducing parasympathetic activity on ocular and cerebral pulsations, inspired by recent discoveries of a glymphatic‐like system in the eye driven by physiological pulsations.
Seyed Mohsen Ebrahimi, Niko Huotari, Ville Saarela, Marja Honkamo, Lauri Raitamaa, Vesa Korhonen, Johanna Tuunanen, Janne Kananen, Vesa Kiviniemi   +8 more
wiley   +1 more source

The Incidence of Benzodiazepine and Benzodiazepine‐Related Drug Use in People With and Without Parkinson's Disease—A Nationwide Cohort Study

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
ABSTRACT Background Non‐motor symptoms of Parkinson's disease (PD), including sleep problems and anxiety, are common and can appear before motor symptoms. Benzodiazepines and benzodiazepine‐related drugs (BZDR) may be used to treat these symptoms, although they are associated with an increased fall risk.
Veera Lonka, Sirpa Hartikainen, Miia Tiihonen, Marjaana Koponen, Anna‐Maija Tolppanen   +4 more
wiley   +1 more source

Potential Involvement of the Ocular Glymphatic System in Optic Disc Edema in Astronauts

, 2020
Peter Wostyn, Frank De Winne, Claudia Stern, Thomas H. Mader, C. Robert Gibson, Peter Paul De Deyn   +5 more
openalex   +2 more sources

Watching the eye with Mars in sight

Experimental Physiology, EarlyView.
Peter zu Eulenburg, Lonnie Petersen, Damian M. Bailey   +2 more
wiley   +1 more source

Morphology of the glymphatic and meningeal lymphatic structures of the bottlenose dolphin

Scientific Reports
In humans and mice, the glymphatic system, critical for central nervous system (CNS) health, relies on cardiorespiratory coupling, but has not yet been investigated in a diving mammal that routinely experiences apnea, bradycardia, and peripheral ...
Tiffany F. Keenan, Olivia N. Jackson, Nathan P. Nelson-Maney, Sentiel A. Rommel, William A. McLellan, D. Ann Pabst, Alexander M. Costidis, Kathleen M. Caron, Dawn N. Kernagis, David S. Rotstein, Molly Braun, Michael S. Tift   +11 more
doaj   +1 more source

Meningeal Lymphatic and Glymphatic Structures in a Pelagic Delphinid (Delphinus delphis)

Animals
The glymphatic system, an analog of the peripheral lymphatic system in the brain, and the meningeal lymphatic system are critical to central nervous system health.
Olivia N. Jackson, Tiffany F. Keenan, Nathan P. Nelson-Maney, Sentiel A. Rommel, William A. McLellan, D. Ann Pabst, Alexander M. Costidis, Kathleen M. Caron, Dawn N. Kernagis, David S. Rotstein, Victoria G. Thayer, Craig A. Harms, Marina A. Piscitelli-Doshkov, Paul Doshkov, Lorian E. Schweikert, Kara E. Yopak, Molly Braun, Michael S. Tift   +17 more
doaj   +1 more source