Results 11 to 20 of about 11,518 (273)
Microglia synchronizes with the circadian rhythm of the glymphatic system and modulates glymphatic system function. [PDF]
IUBMB LifeAbstractMicroglia, as immune cells in the central nervous system, possess the ability to adapt morphologically and functionally to their environment. Glymphatic system, the principal waste clearance system in the brain, exhibits circadian rhythms. However, the impact of microglia on the glymphatic system function remains unknown.
Yang T, Tang Y, Liu X, Gong S, Yao E.
europepmc +4 more sources
Glymphatic system and post-hemorrhagic hydrocephalus
Brain Hemorrhages, 2023 The glymphatic system is a recently identified route for exchanging parenchyma interstitial fluid and cerebrospinal fluid along perivascular space, facilitating brain waste clearance.
Fenghui Ye +4 more
doaj +3 more sources
PDGF-B Is Required for Development of the Glymphatic System [PDF]
Cell Reports, 2019 Summary: The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways.
Anne Sofie Munk +14 more
doaj +8 more sources
Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer’s disease [PDF]
Translational NeurodegenerationThe glymphatic system serves as the brain’s clearance system. It deteriorates with age and is a significant contributor to the onset and progression of Alzheimer’s disease (AD).
Danrui Zhao +11 more
doaj +2 more sources
A clinical primer for the glymphatic system [PDF]
Brain, 2021 Abstract The complex and dynamic system of fluid flow through the perivascular and interstitial spaces of the CNS has new-found implications for neurological diseases. CSF movement throughout the CNS parenchyma is more dynamic than could be explained via passive diffusion mechanisms alone.
Lucas P. Carlstrom +9 more
openalex +3 more sources
Diffusion–tensor MRI study of the relationship between glymphatic system asymmetry and onset lateralization in Parkinson’s disease [PDF]
npj Parkinson's DiseaseThe characteristic asymmetric motor symptoms of Parkinson’s disease (PD) may be associated with asymmetric deposition of α-synuclein. The impaired glymphatic system may promote pathological deposition of α-synuclein, leading to disease progression.
Zihan Li +9 more
doaj +2 more sources
Frontiers in NeurologyAlzheimer’s disease (AD) is the leading type of dementia globally, characterized by a complex pathogenesis that involves various comorbidities. An imbalance in the production and clearance of amyloid β-protein (Aβ) peptides in the brain is a key ...
Hailang Li +4 more
doaj +2 more sources
Magnetic Resonance Imaging and Modeling of the Glymphatic System [PDF]
Diagnostics, 2020 The glymphatic system is a newly discovered waste drainage pathway in the brain; it plays an important role in many neurological diseases. Ongoing research utilizing various cerebrospinal fluid tracer infusions, either directly or indirectly into the ...
Jasleen Kaur +8 more
doaj +3 more sources
The Glymphatic System in Diabetes-Induced Dementia [PDF]
Frontiers in Neurology, 2018 The glymphatic system has emerged as an important player in central nervous system (CNS) diseases, by regulating the vasculature impairment, effectively controlling the clearance of toxic peptides, modulating activity of astrocytes, and being involved in
Young-Kook Kim +4 more
doaj +4 more sources
Neurobiology of DiseaseNeurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial fluid (ISF), facilitates the movement of ...
Yan-rui Sun +4 more
doaj +3 more sources