Results 211 to 220 of about 11,518 (273)

Glymphatic Function in Prodromal Parkinson's Disease: Associations With Symptoms, Gray Matter Volume, and Phenoconversion Risk

open access: yesEuropean Journal of Neurology, Volume 32, Issue 10, October 2025.
ABSTRACT Background and Objectives Glymphatic dysfunction occurs in Parkinson's disease (PD), but its status in prodromal PD (pPD) is unclear. Using the diffusion tensor imaging along perivascular spaces (DTI‐ALPS) index as an indirect proxy, this study aims to evaluate glymphatic‐related changes in a pPD cohort and to explore their relationship with ...
Amei Chen   +8 more
wiley   +1 more source

The Future of Non‐Invasive Brain Stimulation in Sleep Medicine

open access: yesJournal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Non‐invasive brain stimulation (NIBS) methods carry particular appeal as non‐pharmacological approaches to inducing or improving sleep. However, intense research efforts to use transcranial magnetic stimulation (TMS) and electrical stimulation (tES) for sleep modulation have not yet delivered evidence‐based NIBS treatments in sleep medicine ...
Lukas B. Krone   +3 more
wiley   +1 more source

Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy

open access: yesJournal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash   +5 more
wiley   +1 more source

Intrahippocampally Injected Human Recombinant Clusterin Reduces Amyloid‐β Aggregate Size in Cerebral Arteriole Walls of Clusterin Knockout Mice

open access: yesNeuropathology and Applied Neurobiology, Volume 51, Issue 5, October 2025.
This study examined how clusterin influences amyloid beta (Aβ) deposition in the brain's blood vessels using clusterin deficient mice. The presence of human recombinant CLU, introduced by intrahippocampal injection, reduced the size of Aβ deposits in arteriolar walls but did not affect overall Aβ levels. These results suggest CLU plays a direct role in
Alexandru Laslo   +11 more
wiley   +1 more source

Circadian influences on central nervous system barriers and the glymphatic system. [PDF]

open access: yesFront Physiol
Elliott BD   +4 more
europepmc   +1 more source

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