Results 231 to 240 of about 24,909,638 (279)

Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associations

Science Advances
We applied an MRI technique diffusion tensor imaging along the perivascular space (DTI-ALPS) for assessing glymphatic system (GS) in a genome-wide association study (GWAS) and phenome-wide association study (PheWAS) of 40,486 European individuals ...
Lusen Ran, Yuanyuan Fang, Chang Cheng, Yuqin He, Zhonghe Shao, Yifan Kong, Hao Huang, Shabei Xu, Xiang Luo, Wei Wang, Xingjie Hao, Minghuan Wang   +11 more
semanticscholar   +1 more source

The influence of the glymphatic system on α-synuclein propagation: the role of aquaporin-4.

Brain : a journal of neurology
Propagation and aggregation of prion proteins, such as tau and α-synuclein (αSyn), are key pathological features of neurodegenerative diseases. Extracellular clearance pathways, such as the glymphatic system, may play a crucial role in the removal of ...
Douglas M Lopes, Sophie K Llewellyn, Sheila E Bury, Jiazheng Wang, Jack A Wells, M. Gegg, G. Verona, M. Lythgoe, I. Harrison   +8 more
semanticscholar   +1 more source

Glymphatic system dysfunction correlated with gut dysbiosis and cognitive impairment in schizophrenia

Schizophrenia
Structural and functional brain abnormalities in schizophrenia (SZ) are well-documented, yet the role of the glymphatic system remains largely unexplored. Given emerging evidence linking the microbiome-gut-brain axis to SZ, this study aims to investigate
Hui Wu, Bingdong Liu, W. Liu, Zhi Wen, Wenbing Yang, Huaguang Yang, Jianbo Li, Yunfei Zha   +7 more
semanticscholar   +1 more source

[The glymphatic system - an overview].

Lakartidningen, 2023
The glymphatic system as a concept was introduced a decade ago and the knowledge regarding the circulation of the cerebrospinal fluid has since been revised. The research of the glymphatic system is extensive today, but there are many knowledge gaps.
Alba, Corell, Asgeir, S Jakola, Thomas, Skoglund   +2 more
openaire   +1 more source

Advances in the study of the glymphatic system and aging

CNS Neuroscience and Therapeutics
AbstractThe glymphatic system is cerebrospinal fluid–brain tissue fluid exchange flow mediated by aquaporin‐4 (AQP4) on the end feet of astrocytes for a system, which is capable of rapidly removing brain metabolites and thus maintaining brain homeostasis, and is known as the central immune system.
Qingying Yu, Mingjun Xie
exaly   +3 more sources

Exploring glymphatic system alterations in iRBD and Parkinson’s disease using automated DTI-ALPS analysis

npj Parkinson's Disease
Diffusion tensor image analysis along the perivascular space (DTI-ALPS) is a potential non-invasive marker of glymphatic function that typically relies on manual region of interest (ROI) placement.
S. Mareček, V. Rottova, J. Nepožitek, T. Krajca, R. Krupicka, J. Keller, D. Zogala, J. Trnka, K. Šonka, E. Ruzicka, P. Dušek   +10 more
semanticscholar   +1 more source

Glymphatic system dysfunction and cerebrospinal fluid retention in gliomas: evidence from perivascular space diffusion and volumetric analysis

Cancer Imaging
Gliomas may impair glymphatic function and alter cerebrospinal fluid (CSF) dynamics through structural brain changes, potentially affecting peritumoral brain edema (PTBE) and fluid clearance.
Weiqiang Liang, Wenbo Sun, Chunyan Li, Jie Zhou, Changyou Long, Huan Li, Dan Xu, Haibo Xu   +7 more
semanticscholar   +1 more source

Glymphatic system dysfunction in adult ADHD: Relationship to cognitive performance.

Journal of Affective Disorders
OBJECTIVES While attention-deficit/hyperactivity disorder (ADHD) persists into adulthood, the relationship between glymphatic system function and cognitive performance in adult ADHD remains unclear.
Yan Fang, Juan Peng, Tiantian Chu, Feng Gao, Fei Xiong, Ye Tu   +5 more
semanticscholar   +1 more source

Cerebral glymphatic system: structure, regulation, ageing, and mechanisms of encephalopathy.

Ageing Research Reviews
The glymphatic system was initially considered as a perivascular channel, responsible for the clearance of substances within the brain. With the deepening comprehension of the functions of the extracellular space (ECS) and the discovery of meningeal ...
Danrui Zhao, Junting Wang, Fengji Zhang, Qing Wang, M. Zang, Haijing Niu, Zhiqian Tong   +6 more
semanticscholar   +1 more source

Evaluation of glymphatic system dysfunction in patients with insomnia via diffusion tensor image analysis along the perivascular space

Quantitative Imaging in Medicine and Surgery
Background The glymphatic system is a crucial pathway for the clearance of metabolic waste from the brain, and its dysfunction has been linked to various neurodegenerative disorders.
Ruifang Xiong, Jie Feng, Hanting Zhu, Chengyi Li, Pengxin Hu, Yu Zou, Mingyu Zhou, Ye Wang, Xiaoping Tang   +8 more
semanticscholar   +1 more source