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The Glymphatic System (En)during Inflammation [PDF]
International Journal of Molecular Sciences, 2021 The glymphatic system is a fluid-transport system that accesses all regions of the brain. It facilitates the exchange of cerebrospinal fluid and interstitial fluid and clears waste from the metabolically active brain. Astrocytic endfeet and their dense expression of the aquaporin-4 water channels promote fluid exchange between the perivascular spaces ...
Maiken Nedergaard +2 more
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The glymphatic system: implications for drugs for central nervous system diseases
Nature Reviews Drug Discovery, 2022 In the past decade, evidence for a fluid clearance pathway in the central nervous system known as the glymphatic system has grown. According to the glymphatic system concept, cerebrospinal fluid flows directionally through the brain and non-selectively ...
Maiken Nedergaard +2 more
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Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2022
Glymphatic system - is a recently discovered system for waste clearance and solute balance regulation in the brain. In this article we review the modern views on anatomy and physiology of glymphatic system, the factors known to regulate glymphatic flow, as well as the role of glyphatic dysfunction in the development of central nervous system pathology.
N.G. Dudchenko +3 more
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Glymphatic system - is a recently discovered system for waste clearance and solute balance regulation in the brain. In this article we review the modern views on anatomy and physiology of glymphatic system, the factors known to regulate glymphatic flow, as well as the role of glyphatic dysfunction in the development of central nervous system pathology.
N.G. Dudchenko +3 more
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Current Biology, 2021
All biological processes including movement, digestion, and thought require energy, and the metabolic activity necessary to generate that energy also generates waste. Metabolic by-products, including a variety of proteins, accumulate in the tissue and can be harmful if not removed.
Lauren M, Hablitz, Maiken, Nedergaard
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All biological processes including movement, digestion, and thought require energy, and the metabolic activity necessary to generate that energy also generates waste. Metabolic by-products, including a variety of proteins, accumulate in the tissue and can be harmful if not removed.
Lauren M, Hablitz, Maiken, Nedergaard
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The features of the glymphatic system
Autonomic Neuroscience, 2021The glymphatic system creates a network of perivascular channels. It is made of astroglia cells, whose perikaryon extensions strongly express aquaporin-4 water channels (AQP4). The pathways of the glymphatic system ensure the transport of nutrients, including glucose, lipids, amino acids, neurotransmitters, antigens, and immune cells, as well as ...
Kielan, Blanka, Marek Mandera
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The Glymphatic System: A Beginner’s Guide [PDF]
Neurochemical Research, 2015 The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system.
Maiken Nedergaard +2 more
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Impairment of the glymphatic system after diabetes
Journal of Cerebral Blood Flow and Metabolism, 2017 The glymphatic system has recently been shown to clear brain extracellular solutes and abnormalities in glymphatic clearance system may contribute to both initiation and progression of neurological diseases.
Maiken Nedergaard +2 more
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Modeling glymphatic system of the brain using MRI
NeuroImage, 2019 The glymphatic system is functional waste clearance path from the brain parenchyma through dynamic exchange of cerebrospinal fluid (CSF) with interstitial fluid (ISF).
Quan Jiang +2 more
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Advances in the study of the glymphatic system and aging
CNS Neuroscience and TherapeuticsAbstractThe glymphatic system is cerebrospinal fluid–brain tissue fluid exchange flow mediated by aquaporin‐4 (AQP4) on the end feet of astrocytes for a system, which is capable of rapidly removing brain metabolites and thus maintaining brain homeostasis, and is known as the central immune system.
Qingying Yu, Kejian Li, Ming jun Xie
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