Results 191 to 200 of about 9,639 (217)
The glymphatic system: implications for drugs for central nervous system diseases [PDF]
Nature Reviews Drug Discovery, 2022 In the past decade, evidence for a fluid clearance pathway in the central nervous system known as the glymphatic system has grown. According to the glymphatic system concept, cerebrospinal fluid flows directionally through the brain and non-selectively ...
Maiken Nedergaard +2 more
exaly +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2022
Glymphatic system - is a recently discovered system for waste clearance and solute balance regulation in the brain. In this article we review the modern views on anatomy and physiology of glymphatic system, the factors known to regulate glymphatic flow, as well as the role of glyphatic dysfunction in the development of central nervous system pathology.
N.G. Dudchenko +3 more
openaire +2 more sources
Glymphatic system - is a recently discovered system for waste clearance and solute balance regulation in the brain. In this article we review the modern views on anatomy and physiology of glymphatic system, the factors known to regulate glymphatic flow, as well as the role of glyphatic dysfunction in the development of central nervous system pathology.
N.G. Dudchenko +3 more
openaire +2 more sources
Current Biology, 2021
All biological processes including movement, digestion, and thought require energy, and the metabolic activity necessary to generate that energy also generates waste. Metabolic by-products, including a variety of proteins, accumulate in the tissue and can be harmful if not removed.
Lauren M, Hablitz, Maiken, Nedergaard
openaire +2 more sources
All biological processes including movement, digestion, and thought require energy, and the metabolic activity necessary to generate that energy also generates waste. Metabolic by-products, including a variety of proteins, accumulate in the tissue and can be harmful if not removed.
Lauren M, Hablitz, Maiken, Nedergaard
openaire +2 more sources
The features of the glymphatic system
Autonomic Neuroscience, 2021The glymphatic system creates a network of perivascular channels. It is made of astroglia cells, whose perikaryon extensions strongly express aquaporin-4 water channels (AQP4). The pathways of the glymphatic system ensure the transport of nutrients, including glucose, lipids, amino acids, neurotransmitters, antigens, and immune cells, as well as ...
Kielan, Blanka, Marek Mandera
openaire +3 more sources
The Glymphatic System: A Beginner’s Guide [PDF]
Neurochemical Research, 2015 The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system.
Maiken Nedergaard +2 more
exaly +3 more sources
Modeling glymphatic system of the brain using MRI [PDF]
NeuroImage, 2019 The glymphatic system is functional waste clearance path from the brain parenchyma through dynamic exchange of cerebrospinal fluid (CSF) with interstitial fluid (ISF).
Quan Jiang +2 more
exaly +1 more source
The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future [PDF]
Annual Review of Pathology: Mechanisms of Disease, 2018 The central nervous system (CNS) is unique in being the only organ system lacking lymphatic vessels to assist in the removal of interstitial metabolic waste products.
Maiken Nedergaard, Benjamin A Plog
exaly +2 more sources
[The glymphatic system - an overview].
Lakartidningen, 2023The glymphatic system as a concept was introduced a decade ago and the knowledge regarding the circulation of the cerebrospinal fluid has since been revised. The research of the glymphatic system is extensive today, but there are many knowledge gaps.
Alba, Corell +2 more
openaire +1 more source
Advances in the study of the glymphatic system and aging
CNS Neuroscience and TherapeuticsAbstractThe glymphatic system is cerebrospinal fluid–brain tissue fluid exchange flow mediated by aquaporin‐4 (AQP4) on the end feet of astrocytes for a system, which is capable of rapidly removing brain metabolites and thus maintaining brain homeostasis, and is known as the central immune system.
Qingying Yu, Ming Jun Xie
exaly +3 more sources
Adult Hydrocephalus and the Glymphatic System
Neurosurgery Clinics of North AmericaAdult hydrocephalus, especially idiopathic normal pressure hydrocephalus (iNPH), involves cerebrospinal fluid (CSF) dysfunction that is associated with impaired waste clearance in the brain, potentially causing toxic protein buildup. This condition shares features with neurodegenerative diseases like Alzheimer's, where amyloid-β and tau proteins ...
openaire +2 more sources