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The glymphatic system, a brain-wide network-supporting cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange, is essential for removing metabolic waste from the brain. This system's proper functioning is crucial for maintaining neural health and preventing the accumulation of harmful substances that can lead to neurodegenerative diseases ...
Hashmat, Ghanizada, Maiken, Nedergaard
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Hashmat, Ghanizada, Maiken, Nedergaard
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Glymphatic system, sleep, neurodegeneration
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. PavlovaThe prevalence of neurodegenerative diseases and the complexity of their treatment in late stages make it urgent to identify early markers and symptoms of this group of diseases in order to optimize diagnosis, treatment and prevention. Materials and methods.
A. V. Gorbachevskii +2 more
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Glymphatic system dysfunction in neurodegenerative diseases
Current Opinion in NeurologyPurpose of review Purpose of this review is to update the ongoing work in the field of glymphatic and neurodegenerative research and to highlight focus areas that are particularly promising. Recent findings Multiple reports have over the past decade documented that glymphatic fluid ...
Beschorner, Natalie, Nedergaard, Maiken
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[The glymphatic system - an overview].
Lakartidningen, 2023The glymphatic system as a concept was introduced a decade ago and the knowledge regarding the circulation of the cerebrospinal fluid has since been revised. The research of the glymphatic system is extensive today, but there are many knowledge gaps.
Alba, Corell +2 more
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Adult Hydrocephalus and the Glymphatic System
Neurosurgery Clinics of North AmericaAdult hydrocephalus, especially idiopathic normal pressure hydrocephalus (iNPH), involves cerebrospinal fluid (CSF) dysfunction that is associated with impaired waste clearance in the brain, potentially causing toxic protein buildup. This condition shares features with neurodegenerative diseases like Alzheimer's, where amyloid-β and tau proteins ...
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The glymphatic system and Amyotrophic lateral sclerosis
Progress in NeurobiologyThe glymphatic system and the meningeal lymphatic vessels provide a pathway for transport of solutes and clearance of toxic material from the brain. Of specific relevance to ALS, this is applicable for TDP-43 and glutamate, both major elements in disease pathogenesis.
Eisen, Andrew +3 more
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Neurology, Psychiatry and Brain Research, 2016
Helene Benveniste, Maiken Nedergaard
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Helene Benveniste, Maiken Nedergaard
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Sleep and the glymphatic system
American Nurse JournalUnderstanding how sleep works can aid patient assessments and improve overall care.
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The Role of the Glymphatic System
The glymphatic system, a recently identified waste clearance pathway in the brain, is crucial for removing waste products and maintaining brain homeostasis. Similar to the lymphatic system in the body, the glymphatic system operates uniquely within the brain.Gaiqing Wang +5 more
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