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Current Biology, 2021
All biological processes including movement, digestion, and thought require energy, and the metabolic activity necessary to generate that energy also generates waste. Metabolic by-products, including a variety of proteins, accumulate in the tissue and can be harmful if not removed.
Lauren M, Hablitz, Maiken, Nedergaard
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All biological processes including movement, digestion, and thought require energy, and the metabolic activity necessary to generate that energy also generates waste. Metabolic by-products, including a variety of proteins, accumulate in the tissue and can be harmful if not removed.
Lauren M, Hablitz, Maiken, Nedergaard
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Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2022
Glymphatic system - is a recently discovered system for waste clearance and solute balance regulation in the brain. In this article we review the modern views on anatomy and physiology of glymphatic system, the factors known to regulate glymphatic flow, as well as the role of glyphatic dysfunction in the development of central nervous system pathology.
N.G. Dudchenko +3 more
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Glymphatic system - is a recently discovered system for waste clearance and solute balance regulation in the brain. In this article we review the modern views on anatomy and physiology of glymphatic system, the factors known to regulate glymphatic flow, as well as the role of glyphatic dysfunction in the development of central nervous system pathology.
N.G. Dudchenko +3 more
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The features of the glymphatic system
Autonomic Neuroscience, 2021The glymphatic system creates a network of perivascular channels. It is made of astroglia cells, whose perikaryon extensions strongly express aquaporin-4 water channels (AQP4). The pathways of the glymphatic system ensure the transport of nutrients, including glucose, lipids, amino acids, neurotransmitters, antigens, and immune cells, as well as ...
Marek Mandera, Blanka Nycz
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2015
The brain is one of the most metabolically active organs in the body, and continuous removal of excess fluid and waste products is critical for normal brain function. In contrast to other body organs, the brain lack lymphatic vessels for detoxification. In place of lymphatic vessels, the brain uses a so-called glymphatic pathway which comprise the peri-
Benveniste, Helene, Nedergaard, Maiken
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The brain is one of the most metabolically active organs in the body, and continuous removal of excess fluid and waste products is critical for normal brain function. In contrast to other body organs, the brain lack lymphatic vessels for detoxification. In place of lymphatic vessels, the brain uses a so-called glymphatic pathway which comprise the peri-
Benveniste, Helene, Nedergaard, Maiken
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The glymphatic system, a brain-wide network-supporting cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange, is essential for removing metabolic waste from the brain. This system's proper functioning is crucial for maintaining neural health and preventing the accumulation of harmful substances that can lead to neurodegenerative diseases ...
Hashmat, Ghanizada, Maiken, Nedergaard
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Hashmat, Ghanizada, Maiken, Nedergaard
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Adult Hydrocephalus and the Glymphatic System
Neurosurgery Clinics of North AmericaAdult hydrocephalus, especially idiopathic normal pressure hydrocephalus (iNPH), involves cerebrospinal fluid (CSF) dysfunction that is associated with impaired waste clearance in the brain, potentially causing toxic protein buildup. This condition shares features with neurodegenerative diseases like Alzheimer's, where amyloid-β and tau proteins ...
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Glymphatic system dysfunction in neurodegenerative diseases
Current Opinion in NeurologyPurpose of review Purpose of this review is to update the ongoing work in the field of glymphatic and neurodegenerative research and to highlight focus areas that are particularly promising. Recent findings Multiple reports have over the past decade documented that glymphatic fluid ...
Beschorner, Natalie, Nedergaard, Maiken
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The Glymphatic System and its Relationship to Migraine
Current Neurology and Neuroscience ReportsWe aim to critically review animal and human studies of the glymphatic system in migraine and propose a model for how the glymphatic system may function in migraine, based on the available evidence.Early studies in animal models report migraine attacks temporarily disrupt glymphatic flow. Human imaging studies suggest chronic migraine may be associated
Alana Fretes, Burgos +2 more
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