Results 21 to 28 of about 28 (28)

Sleep neuroimaging: Review and future directions

Journal of Sleep Research, EarlyView.
Summary Sleep research has evolved considerably since the first sleep electroencephalography recordings in the 1930s and the discovery of well‐distinguishable sleep stages in the 1950s. While electrophysiological recordings have been used to describe the sleeping brain in much detail, since the 1990s neuroimaging techniques have been applied to uncover
Mariana Pereira, Xinyuan Chen, Anastasiya Paltarzhytskaya, Yibran Pacheсo, Nils Muller, Leonore Bovy, Xu Lei, Wei Chen, Haoran Ren, Chen Song, Laura D. Lewis, Thien Thanh Dang‐Vu, Michael Czisch, Dante Picchioni, Jeff Duyn, Philippe Peigneux, Enzo Tagliazucchi, Martin Dresler   +17 more
wiley   +1 more source

MRI‐based surrogates of brain clearance in narcolepsy type 1

Journal of Sleep Research, EarlyView.
Summary Brain clearance involves the drainage of waste molecules from the brain, a process that is suggested to be amplified during sleep. Recently proposed MRI‐based methods attempt to approximate human brain clearance with surrogate measures. The current study aimed to explore whether two brain clearance surrogates are altered in narcolepsy.
Eva M. van Heese, Jari K. Gool, Gert Jan Lammers, Ysbrand D. van der Werf, Matthias J. P. van Osch, Rolf Fronczek, Lydiane Hirschler   +6 more
wiley   +1 more source

The Sleep Opportunity, Need and Ability (SONA) Theory

Journal of Sleep Research, EarlyView.
ABSTRACT ‘How much sleep does one need?’ is a critical question that has been difficult to answer. The long history of sleep research has culminated in population‐derived normative values of 7 to 9 h of sleep per night to avoid dysfunction. Such a wide range is sufficiently large that one cannot know what is required for any given individual.
Hannah Scott, Michael Perlis
wiley   +1 more source

The Future of Non‐Invasive Brain Stimulation in Sleep Medicine

Journal of Sleep Research, EarlyView.
ABSTRACT Non‐invasive brain stimulation (NIBS) methods carry particular appeal as non‐pharmacological approaches to inducing or improving sleep. However, intense research efforts to use transcranial magnetic stimulation (TMS) and electrical stimulation (tES) for sleep modulation have not yet delivered evidence‐based NIBS treatments in sleep medicine ...
Lukas B. Krone, Seo Ho Song, Valeria Jaramillo, Ines R. Violante   +3 more
wiley   +1 more source

Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy

Journal of Sleep Research, EarlyView.
ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash, Ishani Shah, Guohao Ni, Sridhar Vasudevan, Aarti Jagannath, Russell G. Foster   +5 more
wiley   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, EarlyView.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

Confined spaces in space: Cerebral implications of chronic elevations of inspired carbon dioxide and implications for long‐duration space travel

Experimental Physiology, EarlyView.
Abstract Cerebrovascular regulation is critically dependent upon the arterial partial pressure of carbon dioxide (PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_{\mathrm{2}}}}}$), owing to its effect on cerebral blood flow, tissue PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_{\mathrm{2}}}}}$, tissue proton concentration, cerebral metabolism and cognitive and neuronal ...
Jay M. J. R. Carr, Philip N. Ainslie, Trevor Day   +2 more
wiley   +1 more source

Ultrastructure of astrocytes using volume electron microscopy: A scoping review

The Journal of Physiology, EarlyView.
Abstract figure legend A complete overview on astrocyte ultrastructure with volume electron microscopy. The morphology of astrocytes under physiological and pathological conditions plays a role in brain homeostasis, synaptic activity and structural support, but their morphological complexity and heterogeneity are still poorly quantified.
Vanessa Chiappini, Maria Fernanda Veloz Castillo, Francesco Biancardi, Ferdinando Di Cunto, Pierre J. Magistretti, Alessandro Vercelli, Marco Agus, Corrado Calì   +7 more
wiley   +1 more source