Results 71 to 80 of about 1,028 (203)

REDUCTION OF GLYOXYLATE BY LACTATE DEHYDROGENASE

open access: yesTHE JOURNAL OF VITAMINOLOGY, 1966
Reduction of glyoxylate by lactate dehydrogenase was confirmed through the demonstration of the formation of reaction products, mode of inhibition by trypsin and urea, and the mode of distribution among different organs. In crystalline lactate dehydrogenase, the difference in Km and pH was clearly demonstrated between glyoxylate and pyruvate.
SAWAKI, SHUNJI   +2 more
openaire   +3 more sources

Transcriptional responses of Aedes aegypti chemosensory tissues in response to volatile DEET and citronella oil

open access: yesInsect Molecular Biology, Volume 35, Issue 5, Page 526-540, October 2026.
Aedes aegypti females were significantly repelled by both volatile DEET and citronella oil in comparison to control (ethanol‐exposed) mosquitoes. Global gene expression changes were largest in the mosquito mouthparts, with notable downregulation of the three subunits comprising the mosquito CO2 receptor (Gr1, 2 and 3).
Ivan Drahun   +3 more
wiley   +1 more source

Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain

open access: yesAlzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, we assessed the impact of perinatal Pb exposure on dementia‐related ...
Rachel K. Morgan   +10 more
wiley   +1 more source

Gut–Brain Axis Modulation by Short‐Chain Fatty Acids Exerts Disease‐Modifying Effects in a Murine Model of Drug‐Resistant Epilepsy

open access: yesAnnals of Neurology, Volume 100, Issue 3, Page 613-627, September 2026.
Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera   +16 more
wiley   +1 more source

Assessing the Impact of Multigene Engineering on the Proteome: Omega‐3 Camelina as a Case Study

open access: yes
Plant Biotechnology Journal, EarlyView.
Hongtao Zhang   +2 more
wiley   +1 more source

Metabolomics and Mechanistic Approaches Reveal the Synergistic and Attenuating of Rubus chingii Hu on Tripterygium Glycoside Tablets in the Treatment of Rheumatoid Arthritis

open access: yesChemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Experimental flow chart of the attenuating and synergistic effects of RCH on TGTs in the treatment of rheumatoid arthritis. ABSTRACT Tripterygium Glycoside Tablets (TGTs) are primary drugs for rheumatoid arthritis (RA) but pose a risk of nephrotoxicity. Rubus chingii Hu (RCH) may enhance kidney function.
Cong Zhang   +3 more
wiley   +1 more source

Plasma Exosome Metabolomics Reveal Stage‐Specific Alterations in Elderly Women With Premetabolic and Metabolic Syndrome

open access: yesChronic Diseases and Translational Medicine, Volume 12, Issue 3, Page 219-230, September 2026.
Shared differential metabolites identified across the three sample groups. (A) Venn diagram of differential metabolites between the two comparison groups; Based on the detected levels of these overlapping differential metabolites, (B) d‐Arabitol, (C) Triclosan, (D) Iloprost, (E) Tetracosanoic acid, and (F) Omeprazole sulfone. Box plots were constructed
Mengtao Qian   +4 more
wiley   +1 more source

Hydrazone‐Type Ligands for Asymmetric Catalysis

open access: yesChemistryEurope, Volume 4, Issue 9, September 2026.
The introduction of trans 2,5‐disubstituted pyrrolidines is the key design element enabling the excellent stereocontrol exerted by hydrazone‐based N‐ligands in a variety of transition metal‐catalyzed transformations, including Diels–Alder cycloadditions, Suzuki/Hiyama/Negishi cross‐couplings, 1,2‐additions to a variety of imines and hydrazones, and ...
Esteban Matador   +4 more
wiley   +1 more source

Gut Microbiomes of Two Bamboo Locusts Reveal Divergent Metabolic Potentials

open access: yesEcology and Evolution, Volume 16, Issue 9, September 2026.
We compared the gut microbiota of two bamboo‐feeding locust pests, Ceracris kiangsu and Ceracris nigricornis, using 16S rRNA amplicon sequencing for six geographic populations of C. kiangsu and publicly available C. nigricornis datasets. Both species were dominated by Firmicutes and Proteobacteria, but showed significant differences in community ...
Hong‐Yu Liao   +6 more
wiley   +1 more source

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