Results 261 to 270 of about 195,338 (284)

Targeting GM-CSF in inflammatory diseases

Nature Reviews Rheumatology, 2015
Granulocyte-macrophage colony stimulating factor (GM-CSF) is a growth factor first identified as an inducer of differentiation and proliferation of granulocytes and macrophages derived from haematopoietic progenitor cells. Later studies have shown that GM-CSF is involved in a wide range of biological processes in both innate and adaptive immunity, with
Ian P, Wicks, Andrew W, Roberts
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GM‐CSF‐based cancer vaccines

Immunological Reviews, 2002
Summary: The crafting of genetic and biochemical techniques to identify cancer antigens yielded the unexpected discovery that immune recognition of tumors regularly accompanies cancer development. The failure of the host to suppress tumor formation or attenuate disease progression may thus reflect the limited immunogenicity of nascent tumors.
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GM-CSF Biology.

Growth factors (Chur, Switzerland), 2005
Granulocyte macrophage-colony stimulating factor (GM-CSF) was originally defined by its ability to generate in vitro granulocyte and macrophage colonies from bone marrow precursor cells. Apart from its physiological role in the control of alveolar macrophage development, it now appears more likely that its major role lies in its ability to govern the ...
John A, Hamilton, Gary P, Anderson
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GM-CSF

Inflammatory Bowel Diseases, 2006
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Anti-GM-CSF Titer Predicts Response to GM-CSF Therapy in Pulmonary Alveolar Proteinosis

Clinical Immunology, 2002
Pulmonary alveolar proteinosis (PAP) is an idiopathic disease characterized by the accumulation of surfactant in the pulmonary airspaces. The development of a PAP-like syndrome in the GM-CSF knockout mouse and resolution of disease by local GM-CSF expression strongly implicates GM-CSF in surfactant homeostasis and disease pathogenesis.
Tracey L, Bonfield, Mani S, Kavuru, Mary Jane, Thomassen   +2 more
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Expression of GM-CSF receptor and “in vitro” effects of GM-CSF on human fibroblasts

Life Sciences, 1998
In the present study the effects of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) on fibroblast growth and activity have been studied. In this regard the AA have evaluated in primary cultures of human gengival normal fibroblasts (PG1 cells): a)-the expression of GM-CSF receptor (GM-CSFR) (alfa unit) on the cell surface; b)-the in vitro ...
Postiglione, L, Montagnani, S, RICCIO, ANTONIO, Ladogana, P, Salzano, S, Vallefuoco, L, Rossi, G   +6 more
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GM-CSF in inflammation and autoimmunity

Trends in Immunology, 2002
Granulocyte macrophage-colony stimulating factor (GM-CSF) is now best viewed as a major regulator governing the functions of granulocyte and macrophage lineage populations at all stages of maturation. There is recent evidence for a key role for GM-CSF in inflammatory and autoimmune diseases, therefore making it worthy of consideration for targetting ...
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Emerging clinical uses for GM-CSF

European Journal of Cancer and Clinical Oncology, 1991
variety early in life. Quitting smoking is associated with a dramatic drop in the risks of bladder cancer [7], irrespective of the type of tobacco. In the two studies which considered the effect of quitting separately by type, the relative risk remained well above the level of non-smokers only for smokers of black tobacco.
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G- and GM-CSF

International Journal of Antimicrobial Agents, 1998
M, Middleton, N, Thatcher
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GM-CSF

2001
Katherine A. Fitzgerald, Luke A.J. O'Neill, Andy J.H. Gearing, Robin E. Callard   +3 more
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