Results 241 to 250 of about 332,782 (345)

A Modular Synthesis of Isoindole/Indolizine Hybrids via the 1,3‐Dipolar Cycloaddition of Pyridine‐Based Mesoionics with Benzyne

European Journal of Organic Chemistry, EarlyView.
An approach to prepare pyrido[2,1‐a]isoindoles via the cycloaddition of pyridine‐based 1,3‐dipoles and benzyne is described, offering modular access to a range of substituted products by systematic tuning of the dipole. A modular strategy for the synthesis of fused indolizine/isoindole hybrids, pyrido[2,1‐α]isoindoles, via cycloaddition of pyridine ...
Samira Taghizadeh Nodehi, Mohammad Ghanbari, Bruce A. Arndtsen   +2 more
wiley   +1 more source

GM-CSF improves the receptivity of thin endometrium by promoting glandular and stromal cell proliferation in mice and humans. [PDF]

Cell Death Discov
Xie J, Xu Q, Fu T, Zhu L, Zhu Q, Wang X, Dong Q, Huang G, Li J, Yang Z, Chen M, Luo X.   +11 more
europepmc   +1 more source

Mechanistic and Reactivity Insights into Diboron‐Mediated NN and NN Bond Scission

European Journal of Organic Chemistry, EarlyView.
This review highlights the emerging ability of diboron reagents to cleave both π‐bonded (N=N) and σ‐bonded (N—N) nitrogen–nitrogen linkages, integrating mechanistic understanding with recent synthetic applications. Diboron reagents have emerged as versatile reducing agents capable of transforming a broad range of functional groups through pathways like
Raúl Valderrama‐Callejón, Inés Alonso, M. Belén Cid   +2 more
wiley   +1 more source

Glymphatic dysfunction couples with cortical excitation–inhibition imbalance in epilepsy: Evidence from Rasmussen encephalitis

Epilepsia, EarlyView.
Cong Fu et al. demonstrate that glymphatic system dysfunction is linked to enhanced inhibitory cortical activity using diffusion MRI and EEG. These findings highlight a mechanistic link between perivascular fluid dynamics and neuronal activity, suggesting a role for glymphatic function in maintaining cortical stability in epilepsy.
Cong Fu, Yujiao Yang, Pan Gong, Kun Lv, Yilin Liu, Chongyang Tang, Xiongfei Wang, Lixin Cai, Qingzhu Liu, Yuwu Jiang, Taoyun Ji, Guoming Luan   +11 more
wiley   +1 more source

GM-CSF ameliorates inflammation from Pseudomonas aeruginosa in a juvenile mouse model of burn injury. [PDF]

J Leukoc Biol
Penatzer JA, Chandran R, Barash B, Bodempudi P, Thakkar RK.   +4 more
europepmc   +1 more source

GM-CSF and IL-21-armed oncolytic vaccinia virus significantly enhances anti-tumor activity and synergizes with anti-PD1 immunotherapy in pancreatic cancer [PDF]

Yujing Xuan, Wenyi Yan, Rui Wang, Xibin Wang, Yu Guo, Huilin Dun, Ziyan Huan, Lihua Xu, Ruxia Han, Xianlei Sun, Lingling Si, Nicholas R. Lemoine, Yaohe Wang, Pengju Wang   +13 more
openalex   +1 more source

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee, Rachel C. Hector, Lynn Pezzanite, Eric Gilleland, Marlis L. Rezende   +4 more
wiley   +1 more source

Blood measure of neuronal death is exponentially higher with age, especially in females, and halted in Alzheimer's disease by GM-CSF treatment. [PDF]

Cell Rep Med
Sillau SH, Coughlan C, Ahmed MM, Nair K, Araya P, Galbraith MD, Ritchie A, Ching-Jung Wang A, Elos MT, Bettcher BM, Espinosa JM, Chial HJ, Epperson N, Boyd TD, Potter H.   +14 more
europepmc   +1 more source

Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy

, 2010
Minh Chau Nguyen, Guang Huan Tu, Kathryn Koprivnikar, Melissa Gonzalez-Edick, Karin Jooss, Thomas C. Harding   +5 more
openalex   +2 more sources

Arterial Perivascular Space‐Mediated Solute Transport in the Mouse Brain

Exploration, EarlyView.
The mechanisms underlying solute clearance from the brain parenchyma remain debated, with competing hypotheses involving bulk cerebrospinal fluid flow versus perivascular transport. Using multimodal in vivo imaging and computational modeling in mice, this study demonstrates that arterial pulsation drives bidirectional solute movement within the ...
Shiyong Li, Ye Wang, Guangyu Jia, Yamei Yu, Zhe Zhang, Qi Wang, Kaelyn V. Becker, Jonathan W. Engle, Dawei Jiang, Weibo Cai   +9 more
wiley   +1 more source