Results 41 to 50 of about 680,582 (292)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Emerging trends in research and development on earth abundant materials for ammonia degradation coupled with H2 generation

Science and Technology of Advanced Materials
Ammonia, as an essential and economical fuel, is a key intermediate for the production of innumerable nitrogen-based compounds. Such compounds have found vast applications in the agricultural world, biological world (amino acids, proteins, and DNA), and ...
Zakiullah Zaidi, Kamlesh, Yesleen Gupta, Sandeep Singhai, Manish Mudgal, Archana Singh   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Experimental Investigation of Deviations in Sound Reproduction

Acoustics
Sound reproduction is the electro-mechanical re-creation of sound waves using analogue and digital audio equipment. Although sound reproduction implies that repeated acoustical events are close to identical, numerous fixed and variable conditions affect ...
Paul Oomen, Bashar Farran, Luka Nadiradze, Máté Csanád, Amira Val Baker   +4 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Study on Seasonal Variation of Cohesive Suspended Sediment Transport in Estuary of Mahakam Delta by using A Numerical Model

Jurnal Teknik Sipil, 2010
. A coupled three-dimensional hydrodynamics and sediment transport model of HydroQual, Inc., (2002), ECOMSED, has been used to simulate variation of suspended cohesive sediment transport in Estuary of Mahakam Delta.
Safwan Hadi, Nining Sari Ningsih, Ayi Tarya   +2 more
doaj  

Parity of esteem and systems thinking: a theory informed qualitative inductive thematic analysis

BMC Psychiatry, 2022
Background Parity of Esteem (PoE) is about equality between mental and physical health but is a term lacking definition and clarity. The complexity of the field of mental health and the conversations around PoE add to its opacity.
Janine Owens, Karina Lovell, Abigail Brown, Penny Bee   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Comment on “Sedimentation Controls on Methane‐Hydrate Dynamics Across Glacial/Interglacial Stages: An Example From International Ocean Discovery Program Site U1517, Hikurangi Margin” by E. J. Screaton et al.

Geochemistry, Geophysics, Geosystems, 2020
In the IODP 372A proposal, working hypotheses used with respect to actively deforming gas hydrate‐bearing landslides were based on an initial calculation considering gas hydrate to occur in fresh water.
Nabil Sultan
doaj   +1 more source

Effect of AlSi coating on laser spot welding of press hardened steel and process improvement with annular stirring

Materials & Design, 2020
Laser spot welding method was employed to fabricate AlSi coated press-hardened steel (PHS) joints in overlapped configuration. Al and Si segregate at the notch root of a laser spot weld of AlSi coated PHS resulting in pre-mature cracking and weakening ...
Nannan Chen, Zixuan Wan, Hui-Ping Wang, Jingjing Li, Joshua Solomon, Blair E. Carlson   +5 more
doaj   +1 more source