Results 71 to 80 of about 2,890 (187)

Behavioral Deficits in Juvenile Onset Huntington’s Disease

Brain Sciences, 2020
Reports of behavioral disturbance in Juvenile-Onset Huntington’s Disease (JOHD) have been based primarily on qualitative caregiver reports or retrospective medical record reviews.
Kathleen E. Langbehn, Ashley M. Cochran, Ellen van der Plas, Amy L. Conrad, Eric Epping, Erin Martin, Patricia Espe-Pfeifer, Peg Nopoulos   +7 more
doaj   +1 more source

Lactylation in colorectal cancer: Unveiling novel mechanisms in metabolism, progression and therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Lactate accumulation links metabolic reprogramming to epigenetic regulation via protein lactylation. Lactylation drives colorectal cancer proliferation, metastasis, immune escape and chemoresistance. Microbiota‐derived lactate shapes a tumour‐specific lactylation landscape in colorectal cancer.
Ming Liu, Weiwei Li, Yi Ji, Yanqing Chen, Guoli Wei, Jiege Huo, Tao Gui   +6 more
wiley   +1 more source

Myasthenia Gravis With Acetylcholine Receptor Antibodies in the Very Old: Treatment Challenges and Diagnostic Pitfalls

European Journal of Neurology, Volume 33, Issue 2, February 2026.
Myasthenia gravis in the very old and with debut after age 65 years increases in incidence and prevalence. Early, active symptomatic and immunosuppressive treatment is needed with the aim of obtaining pharmacological remission or minimal manifestations only. Myasthenic crisis with respiratory failure remains a threat.
Nils Erik Gilhus
wiley   +1 more source

Clinical and Genomic Evaluation of 207 Genetic Myopathies in the Indian Subcontinent

Frontiers in Neurology, 2020
Objective: Inherited myopathies comprise more than 200 different individually rare disease-subtypes, but when combined together they have a high prevalence of 1 in 6,000 individuals across the world.
Samya Chakravorty, Samya Chakravorty, Samya Chakravorty, Samya Chakravorty, Babi Ramesh Reddy Nallamilli, Satish Vasant Khadilkar, Satish Vasant Khadilkar, Satish Vasant Khadilkar, Madhu Bala Singla, Madhu Bala Singla, Madhu Bala Singla, Ashish Bhutada, Rashna Dastur, Pradnya Satish Gaitonde, Laura E Rufibach, Logan Gloster, Logan Gloster, Madhuri Hegde, Madhuri Hegde   +18 more
doaj   +1 more source

Integrative Analysis of Cytotoxic Lymphocytes‐Mediated Tumour Killing Related Genes Reveals LDHA as a Novel Glioblastoma Therapeutic Target

Journal of Cellular and Molecular Medicine, Volume 30, Issue 4, February 2026.
ABSTRACT Glioblastoma (GBM) features profound immunosuppression and metabolic reprogramming that undermine immunotherapy. We sought biomarkers that capture cytotoxic lymphocyte activity and nominate tractable targets. Using TCGA, we quantified NK/CD8+ T‐cell infiltration (CIBERSORTx), identified differentially expressed genes and derived a three‐gene ...
Shaojie Yu, Xudong Li, Ji Wu, Minjie Wang, Zihan Gong, Baowen Zhang, Haojun Shi, Xuan Wang, Wei Xiang   +8 more
wiley   +1 more source

Exome sequencing identifies novel and known mutations in families with intellectual disability

BMC Medical Genomics, 2021
Background Intellectual disability (ID) is a phenotypically and genetically heterogeneous disorder. Methods In this study, genome wide SNP microarray and whole exome sequencing are used for the variant identification in eight Pakistani families with ID ...
Memoona Rasheed, Valeed Khan, Ricardo Harripaul, Maimoona Siddiqui, Madiha Amin Malik, Zahid Ullah, Muhammad Zahid, John B. Vincent, Muhammad Ansar   +8 more
doaj   +1 more source

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, Volume 158, Issue 2, Page 423-432, 15 January 2026.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source

Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Overview of Sructure, Multienzyme‐mimicking Activity and Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase. Abstract Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis.
Kai Song, Yu Wei, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu   +9 more
wiley   +1 more source

Fighting the Cause of Alzheimer’s and GNE Myopathy

Frontiers in Neuroscience, 2018
Age is the common risk factor for both neurodegenerative and neuromuscular diseases. Alzheimer disease (AD), a neurodegenerative disorder, causes dementia with age progression while GNE myopathy (GNEM), a neuromuscular disorder, causes muscle ...
Shreedarshanee Devi, Rashmi Yadav, Pratibha Chanana, Ranjana Arya   +3 more
doaj   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source